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High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study

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Tameside and Glossop Integrated Care NHS Foundation Trust, Fountain Street, Ashton-under-Lyne OL6 9RW, UK
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The University of Manchester, Oxford Road, Manchester M13 9PL, UK
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Royal Preston Hospital, Lancashire Teaching Hospitals NHS Foundation Trust, Sharoe Green Lane, Fulwood, Preston PR2 9HT, UK
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Manchester Metropolitan University, All Saints Building, Oxford Road, Manchester M15 6BH, UK
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Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Infirmary Square, Leicester LE1 5WW, UK
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Leicester General Hospital, University Hospitals of Leicester NHS Trust, Gwendolen Road, Leicester LE5 4PW, UK
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Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3799; https://doi.org/10.3390/nu12123799
Received: 15 November 2020 / Revised: 2 December 2020 / Accepted: 9 December 2020 / Published: 11 December 2020
(This article belongs to the Section Nutrition and Public Health)
The worldwide pandemic of 2019 novel coronavirus disease (COVID-19) has posed the most substantial and severe public health issue for several generations, and therapeutic options have not yet been optimised. Vitamin D (in its “parent” form, cholecalciferol) has been proposed in the pharmacological management of COVID-19 by various sources. We aimed to determine whether COVID-19 mortality was affected by serum 25-hydroxyvitamin D (25(OH)D) levels, vitamin D status, or cholecalciferol therapy, and to elucidate any other predictors of COVID-19 mortality. Patients hospitalised with COVID-19 were opportunistically recruited from three UK hospitals, and their data were collected retrospectively. Logistic regression was used to determine any relationships between COVID-19 mortality and potential predictors, including 25(OH)D levels and cholecalciferol booster therapy. A total of 986 participants with COVID-19 were studied, of whom 151 (16.0%) received cholecalciferol booster therapy. In the primary cohort of 444 patients, cholecalciferol booster therapy was associated with a reduced risk of COVID-19 mortality, following adjustment for potential confounders (ORadj 0.13, 95% CI 0.05–0.35, p < 0.001). This finding was replicated in a validation cohort of 541 patients (ORadj 0.38, 95% CI 0.17–0.84, p = 0.018). In this observational study, treatment with cholecalciferol booster therapy, regardless of baseline serum 25(OH)D levels, appears to be associated with a reduced risk of mortality in acute in-patients admitted with COVID-19. Further work with large population studies needs to be carried out to determine adequate serum 25(OH)D levels, as well as multi-dose clinical trials of cholecalciferol therapy to assess maximum efficacy. View Full-Text
Keywords: SARS-CoV-2; COVID-19; vitamin D; mortality; cholecalciferol; 25-hydroxyvitamin D; vitamin D treatment; novel coronavirus 2019 SARS-CoV-2; COVID-19; vitamin D; mortality; cholecalciferol; 25-hydroxyvitamin D; vitamin D treatment; novel coronavirus 2019
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MDPI and ACS Style

Ling, S.F.; Broad, E.; Murphy, R.; Pappachan, J.M.; Pardesi-Newton, S.; Kong, M.-F.; Jude, E.B. High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study. Nutrients 2020, 12, 3799. https://doi.org/10.3390/nu12123799

AMA Style

Ling SF, Broad E, Murphy R, Pappachan JM, Pardesi-Newton S, Kong M-F, Jude EB. High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study. Nutrients. 2020; 12(12):3799. https://doi.org/10.3390/nu12123799

Chicago/Turabian Style

Ling, Stephanie F., Eleanor Broad, Rebecca Murphy, Joseph M. Pappachan, Satveer Pardesi-Newton, Marie-France Kong, and Edward B. Jude 2020. "High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study" Nutrients 12, no. 12: 3799. https://doi.org/10.3390/nu12123799

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