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Article

Impact of Long-Term Supplementation with Fish Oil in Individuals with Non-Alcoholic Fatty Liver Disease: A Double Blind Randomized Placebo Controlled Clinical Trial

1
Institute of Nutrition Josué de Castro of Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21.941-902, Brazil
2
Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20559-900, Brazil
3
Department of Internal Medicine, University Hospital Clementino Fraga Filho, School of Medicine of UFRJ, Rio de Janeiro 21.941-902, Brazil
4
Laboratory of Epigenetics of Lipid Metabolism, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM+CSIC, 28049 Madrid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3372; https://doi.org/10.3390/nu12113372
Received: 9 October 2020 / Revised: 27 October 2020 / Accepted: 30 October 2020 / Published: 2 November 2020
(This article belongs to the Special Issue Health Benefits of Edible Oils)
Non-alcoholic fatty liver disease (NAFLD) is a chronic disease affecting up to 25% of the population worldwide. n-3 long-chain polyunsaturated fatty acids (n-3 PUFA) have been associated with improved clinical parameters of NAFLD. Our purpose was to conduct a pilot study to evaluate the effects of n-3 PUFA supplementation in a randomized, double-blind, placebo-controlled clinical study performed on NAFLD individuals diagnosed by ultrasound. Patients received n-3 PUFA (n = 13) or placebo (n = 11) supplementation for six months. Circulating miR-122 expression (determined by quantitative real time-polymerase chain reaction (qRT-PCR), liver fibrosis (FibroScan®), red blood cells (RBC) fatty acids (gas chromatography), and biochemical tests were performed at baseline and after intervention. After the intervention, in the n-3 PUFA group, docosahexaenoic acid (DHA) and omega index increased significantly in RBC (p = 0.022 and p = 0.012, respectively), in addition to a significant reduction in alkaline phosphatase (ALP) (p = 0.002) and liver fibrosis (p = 0.039). However, there was no change in the expression of circulating miR-122 in both groups. Our results showed that omega-3 PUFA were incorporated in erythrocytes after six months of fish oil supplementary intake, and that n-3 PUFA were effective in reducing ALP and liver fibrosis without altering the expression of circulating miR-122 in individuals with NAFLD. View Full-Text
Keywords: NAFLD; miRNA; miR-122; polyunsaturated fatty acid; fish oil; liver fibrosis; alkaline phosphatase NAFLD; miRNA; miR-122; polyunsaturated fatty acid; fish oil; liver fibrosis; alkaline phosphatase
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MDPI and ACS Style

Cansanção, K.; Citelli, M.; Carvalho Leite, N.; López de las Hazas, M.-C.; Dávalos, A.; Tavares do Carmo, M.d.G.; Peres, W.A.F. Impact of Long-Term Supplementation with Fish Oil in Individuals with Non-Alcoholic Fatty Liver Disease: A Double Blind Randomized Placebo Controlled Clinical Trial. Nutrients 2020, 12, 3372. https://doi.org/10.3390/nu12113372

AMA Style

Cansanção K, Citelli M, Carvalho Leite N, López de las Hazas M-C, Dávalos A, Tavares do Carmo MdG, Peres WAF. Impact of Long-Term Supplementation with Fish Oil in Individuals with Non-Alcoholic Fatty Liver Disease: A Double Blind Randomized Placebo Controlled Clinical Trial. Nutrients. 2020; 12(11):3372. https://doi.org/10.3390/nu12113372

Chicago/Turabian Style

Cansanção, Kátia; Citelli, Marta; Carvalho Leite, Nathalie; López de las Hazas, María-Carmen; Dávalos, Alberto; Tavares do Carmo, Maria d.G.; Peres, Wilza A.F. 2020. "Impact of Long-Term Supplementation with Fish Oil in Individuals with Non-Alcoholic Fatty Liver Disease: A Double Blind Randomized Placebo Controlled Clinical Trial" Nutrients 12, no. 11: 3372. https://doi.org/10.3390/nu12113372

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