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Open AccessArticle

Dietary Silk Peptide Prevents High-Fat Diet-Induced Obesity and Promotes Adipose Browning by Activating AMP-Activated Protein Kinase in Mice

1
Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam 13488, Korea
2
Worldway Co., Ltd., Sanda-gil, Jeonul-myeon, Sejong-si 30003, Korea
*
Author to whom correspondence should be addressed.
This author contributed to this work.
Nutrients 2020, 12(1), 201; https://doi.org/10.3390/nu12010201
Received: 11 December 2019 / Revised: 4 January 2020 / Accepted: 9 January 2020 / Published: 13 January 2020
(This article belongs to the Special Issue Diet, Nutrition and Abdominal Obesity)
Obesity is associated with metabolic syndrome and other chronic diseases, and is caused when the energy intake is greater than the energy expenditure. We aimed to determine the mechanism whereby acid-hydrolyzed silk peptide (SP) prevents high-fat diet-induced obesity, and whether it induces browning and fatty acid oxidation (FAO) in white adipose tissue (WAT), using in vivo and ex vivo approaches. We determined the effects of dietary SP in high-fat diet-fed obese mice. The expression of adipose tissue-specific genes was quantified by western blotting, qRT-PCR, and immunofluorescence analysis. We also investigated whether SP directly induces browning in primarily subcutaneous WAT-derived adipocytes. Our findings demonstrate that SP has a browning effect in WAT by upregulating AMP-activated Protein Kinase (AMPK) phosphorylation and uncoupling protein 1 (UCP1) expression. SP also suppresses adipogenesis and promotes FAO, implying that it may have potential as an anti-obesity drug. View Full-Text
Keywords: AMP-activated protein kinase; browning; fatty acid oxidation; obesity; silk peptide AMP-activated protein kinase; browning; fatty acid oxidation; obesity; silk peptide
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MDPI and ACS Style

Lee, K.; Jin, H.; Chei, S.; Lee, J.-Y.; Oh, H.-J.; Lee, B.-Y. Dietary Silk Peptide Prevents High-Fat Diet-Induced Obesity and Promotes Adipose Browning by Activating AMP-Activated Protein Kinase in Mice. Nutrients 2020, 12, 201.

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