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Targeting Abdominal Obesity and Its Complications with Dietary Phytoestrogens

Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Street, 02-106 Warsaw, Poland
Department of Geriatrics and Gerontology, Medical Centre of Postgraduate Education, 61/63 Kleczewska Street, 01-826, Warsaw, Poland
Author to whom correspondence should be addressed.
Nutrients 2020, 12(2), 582;
Received: 10 January 2020 / Revised: 19 February 2020 / Accepted: 20 February 2020 / Published: 23 February 2020
(This article belongs to the Special Issue Diet, Nutrition and Abdominal Obesity)
In the assessment of the health risk of an obese individual, both the amount of adipose tissue and its distribution and metabolic activity are essential. In adults, the distribution of adipose tissue differs in a gender-dependent manner and is regulated by sex steroids, especially estrogens. Estrogens affect adipocyte differentiation but are also involved in the regulation of the lipid metabolism, insulin resistance, and inflammatory activity of the adipose tissue. Their deficiency results in unfavorable changes in body composition and increases the risk of metabolic complications, which can be partially reversed by hormone replacement therapy. Therefore, the idea of the supplementation of estrogen-like compounds to counteract obesity and related complications is compelling. Phytoestrogens are natural plant-derived dietary compounds that resemble human estrogens in their chemical structure and biological activity. Supplementation with phytoestrogens may confer a range of beneficial effects. However, results of studies on the influence of phytoestrogens on body composition and prevalence of obesity are inconsistent. In this review, we present data from in vitro, animal, and human studies regarding the role of phytoestrogens in adipose tissue development and function in the context of their potential application in the prevention of visceral obesity and related complications. View Full-Text
Keywords: phytoestrogens; diet; obesity; adipose tissue; metabolic syndrome phytoestrogens; diet; obesity; adipose tissue; metabolic syndrome
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MDPI and ACS Style

Kuryłowicz, A.; Cąkała-Jakimowicz, M.; Puzianowska-Kuźnicka, M. Targeting Abdominal Obesity and Its Complications with Dietary Phytoestrogens. Nutrients 2020, 12, 582.

AMA Style

Kuryłowicz A, Cąkała-Jakimowicz M, Puzianowska-Kuźnicka M. Targeting Abdominal Obesity and Its Complications with Dietary Phytoestrogens. Nutrients. 2020; 12(2):582.

Chicago/Turabian Style

Kuryłowicz, Alina, Marta Cąkała-Jakimowicz, and Monika Puzianowska-Kuźnicka. 2020. "Targeting Abdominal Obesity and Its Complications with Dietary Phytoestrogens" Nutrients 12, no. 2: 582.

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