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Open AccessArticle

Aqueous Partition of Methanolic Extract of Dicranopteris linearis Leaves Protects against Liver Damage Induced by Paracetamol

1
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia
2
Integrative Pharmacogenomics Institute (I-PROMISE), Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam 42300, Selangor, Malaysia
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 2945; https://doi.org/10.3390/nu11122945
Received: 6 September 2019 / Revised: 9 October 2019 / Accepted: 11 October 2019 / Published: 4 December 2019
(This article belongs to the Special Issue Benefits of Dietary Phytochemicals)
This study aimed to determine the antioxidant and hepatoprotective activities of semi-purified aqueous partition obtained from the methanol extract of Dicranopteris linearis (AQDL) leaves against paracetamol (PCM)-induced liver intoxication in rats. The test solutions, AQDL (50, 250, and 500 mg/kg), were administered orally to rats (n = 6) once daily for seven consecutive days followed by the hepatotoxicity induction using 3 g/kg PCM (p.o.). Blood was collected for serum biochemical parameters analysis while the liver was collected for histopathological examination and endogenous antioxidant enzymes analysis. AQDL was also subjected to antioxidant determination and phytochemical analysis. Results obtained show that AQDL possessed high total phenolic content (TPC) value and remarkable radical scavenging activities. AQDL also significantly (p < 0.05) reduced the liver weight/body weight (LW/BW) ratio or serum level of ALT, AST, and total bilirubin while significantly (p < 0.05) increase the level of superoxide dismutase (SOD) and catalase (CAT) without affecting the malondialdehyde (MDA) in the liver indicating its hepatoprotective effect. Phytoconstituents analyses showed only the presence of saponins and triterpenes, but lack of flavonoids. In conclusion, AQDL exerts hepatoprotective activity via its high antioxidant potential and ability to modulate the endogenous enzymatic antioxidant defense system possibly via the synergistic action of saponins and triterpenes. View Full-Text
Keywords: Dicranopteris linearis; hepatoprotective; free radical scavenging activity; endogenous antioxidant enzymes; saponins; triterpenes; phenolic derivatives Dicranopteris linearis; hepatoprotective; free radical scavenging activity; endogenous antioxidant enzymes; saponins; triterpenes; phenolic derivatives
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Zakaria, Z.A.; Kamisan, F.H.; Mohd. Nasir, N.; Teh, L.K.; Salleh, M.Z. Aqueous Partition of Methanolic Extract of Dicranopteris linearis Leaves Protects against Liver Damage Induced by Paracetamol. Nutrients 2019, 11, 2945.

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