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Open AccessArticle

Energy Expenditure in Older People Hospitalized for an Acute Episode

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Department of Geriatric Medicine, Groupement Hospitalier Sud, CHU de Lyon, 69495 Bénite-Pierre CEDEX, France
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CarMeN, U1060 INSERM, 69921 Oullins CEDEX, France
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Rhône-Alpes Center for Research in Human Nutrition, European Center for Nutrition and Health, Groupement Hospitalier Sud, CHU de Lyon, 69495 Pierre-Bénite CEDEX, France
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Université Claude Bernard Lyon 1, 69100 Villeurbanne, France
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HESPER, EA 7425 Université Claude Bernard lyon 1, 69373 Lyon 8 CEDEX, France
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Department of Biostatistics, Health sciences department, Hospices Civils de Lyon, 69003 Lyon, France
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CNRS UMR 5558, Laboratory of Biometry and evolutive Biology, Biostatistics and health, 69100 Villeurbanne, France
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Center of clinical investigations, Hôpital Louis Pradel, 69500 Bron, France
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Department of endocrinology and Nutrition, Groupement Hospitalier Sud, CHU de Lyon, 69495 Pierre-Bénite CEDEX, France
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Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 2946; https://doi.org/10.3390/nu11122946
Received: 14 November 2019 / Revised: 27 November 2019 / Accepted: 27 November 2019 / Published: 4 December 2019
Weight loss and worsening of nutritional state is a frequent downfall of acute hospitalization in older people. It is usually accepted that acute inflammation is responsible for hypercatabolism. However, several studies suggest, on the contrary, a reduction in resting energy expenditure (REE). This study aimed to obtain a reliable measure of REE and total energy expenditure (TEE) in older patients hospitalized for an acute episode in order to better assess patients’ energy requirements and help understand the mechanisms of weight loss in this situation. Nineteen hospitalized older patients (mean age 83 years) with C-reactive protein (CRP) level >20mg/L were recruited. REE and TEE were measured using gold standard methods of indirect calorimetry and doubly labeled water (DLW), respectively. REE was then compared to data from a previous study on aged volunteers from nursing homes who were free of an acute stressor event. Energy requirements measured by DLW were confirmed at 1.3 × REE. Energy intake covered the needs but did not prevent weight loss in these patients. TEE was not increased in hospitalized patients and was not influenced by inflammation, while the relationship between REE and inflammation was uncertain. Our results suggest that lean mass remains the major determinant of REE in hospitalized older people and that weight loss may not be explained solely by a state of hypercatabolism. View Full-Text
Keywords: doubly labeled water; energy expenditure; energy requirements; energy metabolism; body composition; aged; frail elderly doubly labeled water; energy expenditure; energy requirements; energy metabolism; body composition; aged; frail elderly
MDPI and ACS Style

Bonnefoy, M.; Gilbert, T.; Normand, S.; Jauffret, M.; Roy, P.; Morio, B.; Cornu, C.; Roche, S.; Laville, M. Energy Expenditure in Older People Hospitalized for an Acute Episode. Nutrients 2019, 11, 2946.

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