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Dietary Compounds for Targeting Prostate Cancer

1
College of Korean Medicine, Kyung Hee University, Seoul 02453, Korea
2
Department of Pathology, College of Korean Medicine, Graduate School, Kyung Hee University, Seoul 02453, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2401; https://doi.org/10.3390/nu11102401
Received: 10 August 2019 / Revised: 14 September 2019 / Accepted: 17 September 2019 / Published: 8 October 2019
(This article belongs to the Special Issue Nutrition and Apoptosis)
Prostate cancer is the third most common cancer worldwide, and the burden of the disease is increased. Although several chemotherapies have been used, concerns about the side effects have been raised, and development of alternative therapy is inevitable. The purpose of this study is to prove the efficacy of dietary substances as a source of anti-tumor drugs by identifying their carcinostatic activities in specific pathological mechanisms. According to numerous studies, dietary substances were effective through following five mechanisms; apoptosis, anti-angiogenesis, anti-metastasis, microRNA (miRNA) regulation, and anti-multi-drug-resistance (MDR). About seventy dietary substances showed the anti-prostate cancer activities. Most of the substances induced the apoptosis, especially acting on the mechanism of caspase and poly adenosine diphosphate ribose polymerase (PARP) cleavage. These findings support that dietary compounds have potential to be used as anticancer agents as both food supplements and direct clinical drugs. View Full-Text
Keywords: dietary compounds; natural compounds; prostate cancer; apoptosis; angiogenesis; metastasis; MiRNA; multi drug resistance dietary compounds; natural compounds; prostate cancer; apoptosis; angiogenesis; metastasis; MiRNA; multi drug resistance
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MDPI and ACS Style

Noh, S.; Choi, E.; Hwang, C.-H.; Jung, J.H.; Kim, S.-H.; Kim, B. Dietary Compounds for Targeting Prostate Cancer. Nutrients 2019, 11, 2401.

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