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Open AccessReview

Herbal Medicines Attenuate PD-L1 Expression to Induce Anti-Proliferation in Obesity-Related Cancers

1
Joint Biobank, Office of Human Research, Taipei Medical University, Taipei 11031, Taiwan
2
Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan
3
Taipei Cancer Center, Taipei Medical University, Taipei 11031, Taiwan
4
Center for Immunology and Microbial Diseases, Albany Medical College, Albany, NY 12208, USA
5
Cancer Center, Wang-Fan Hospital, Taipei Medical University, Taipei 11031, Taiwan
6
Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
7
TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan
8
Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan
9
Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12208, USA
10
Department of Medicine, Albany Medical College, Albany, NY 12208, USA
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 2979; https://doi.org/10.3390/nu11122979
Received: 21 October 2019 / Revised: 27 November 2019 / Accepted: 2 December 2019 / Published: 5 December 2019
(This article belongs to the Special Issue Nutrition and Apoptosis)
Pro-inflammatory hormones and cytokines (leptin, tumor necrosis factor (TNF)-α, and interleukin (IL)-6) rise in obesity. Elevated levels of hormones and cytokines are linked with several comorbidities such as diabetes, heart disease, and cancer. The checkpoint programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) plays an important role in obesity and cancer proliferation. L-thyroxine (T4) and steroid hormones up-regulate PD-L1 accumulation and promote inflammation in cancer cells and diabetics. On the other hand, resveratrol and other herbal medicines suppress PD-L1 accumulation and reduce diabetic effects. In addition, they induce anti-cancer proliferation in various types of cancer cells via different mechanisms. In the current review, we discuss new findings and visions into the antagonizing effects of hormones on herbal medicine-induced anti-cancer properties. View Full-Text
Keywords: thyroid hormone; steroid hormone; resveratrol; curcumin; anoectochilus formosanus hayata; PD-L1 thyroid hormone; steroid hormone; resveratrol; curcumin; anoectochilus formosanus hayata; PD-L1
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Yang, Y.-C.S.; Li, Z.-L.; Shih, Y.-J.; Bennett, J.A.; Whang-Peng, J.; Lin, H.-Y.; Davis, P.J.; Wang, K. Herbal Medicines Attenuate PD-L1 Expression to Induce Anti-Proliferation in Obesity-Related Cancers. Nutrients 2019, 11, 2979.

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