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Nutrients
Volume 11
Issue 1
10.3390/nu11010209
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Article

Effects of Dietary Protein and Fat Content on Intrahepatocellular and Intramyocellular Lipids during a 6-Day Hypercaloric, High Sucrose Diet: A Randomized Controlled Trial in Normal Weight Healthy Subjects

by
Anna Surowska
1,†,
Prasanthi Jegatheesan
1,†,
Vanessa Campos
1,
Anne-Sophie Marques
1,
Léonie Egli
1,
Jérémy Cros
1,
Robin Rosset
1,
Virgile Lecoultre
1,
Roland Kreis
2,
Chris Boesch
2,
Bertrand Pouymayou
2,
Philippe Schneiter
1 and
Luc Tappy
1,*
1
Department of Physiology, University of Lausanne, 1005 Lausanne, Switzerland
2
Department for Biomedical Research, University of Bern and Institute of Diagnostic Interventional and Pediatric Radiology, University Hospital, 3012 Bern, Switzerland
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2019, 11(1), 209; https://doi.org/10.3390/nu11010209
Submission received: 14 November 2018 / Revised: 14 January 2019 / Accepted: 15 January 2019 / Published: 21 January 2019
(This article belongs to the Special Issue The Effect of Diet and Nutrition on Postprandial Metabolism)
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Abstract

Sucrose overfeeding increases intrahepatocellular (IHCL) and intramyocellular (IMCL) lipid concentrations in healthy subjects. We hypothesized that these effects would be modulated by diet protein/fat content. Twelve healthy men and women were studied on two occasions in a randomized, cross-over trial. On each occasion, they received a 3-day 12% protein weight maintenance diet (WM) followed by a 6-day hypercaloric high sucrose diet (150% energy requirements). On one occasion the hypercaloric diet contained 5% protein and 25% fat (low protein-high fat, LP-HF), on the other occasion it contained 20% protein and 10% fat (high protein-low fat, HP-LF). IHCL and IMCL concentrations (magnetic resonance spectroscopy) and energy expenditure (indirect calorimetry) were measured after WM, and again after HP-LF/LP-HF. IHCL increased from 25.0 ± 3.6 after WM to 147.1 ± 26.9 mmol/kg wet weight (ww) after LP-HF and from 30.3 ± 7.7 to 57.8 ± 14.8 after HP-LF (two-way ANOVA with interaction: p < 0.001 overfeeding x protein/fat content). IMCL increased from 7.1 ± 0.6 to 8.8 ± 0.7 mmol/kg ww after LP-HF and from 6.2 ± 0.6 to 6.9 ± 0.6 after HP-LF, (p < 0.002). These results indicate that liver and muscle fat deposition is enhanced when sucrose overfeeding is associated with a low protein, high fat diet compared to a high protein, low fat diet.
Keywords: sucrose overfeeding; hepatic steatosis; intramyocellular lipids; intrahepatocellular lipids; dietary protein content; dietary fat content; energy expenditure; plasma triglyceride sucrose overfeeding; hepatic steatosis; intramyocellular lipids; intrahepatocellular lipids; dietary protein content; dietary fat content; energy expenditure; plasma triglyceride

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MDPI and ACS Style

Surowska, A.; Jegatheesan, P.; Campos, V.; Marques, A.-S.; Egli, L.; Cros, J.; Rosset, R.; Lecoultre, V.; Kreis, R.; Boesch, C.; et al. Effects of Dietary Protein and Fat Content on Intrahepatocellular and Intramyocellular Lipids during a 6-Day Hypercaloric, High Sucrose Diet: A Randomized Controlled Trial in Normal Weight Healthy Subjects. Nutrients 2019, 11, 209. https://doi.org/10.3390/nu11010209

AMA Style

Surowska A, Jegatheesan P, Campos V, Marques A-S, Egli L, Cros J, Rosset R, Lecoultre V, Kreis R, Boesch C, et al. Effects of Dietary Protein and Fat Content on Intrahepatocellular and Intramyocellular Lipids during a 6-Day Hypercaloric, High Sucrose Diet: A Randomized Controlled Trial in Normal Weight Healthy Subjects. Nutrients. 2019; 11(1):209. https://doi.org/10.3390/nu11010209

Chicago/Turabian Style

Surowska, Anna, Prasanthi Jegatheesan, Vanessa Campos, Anne-Sophie Marques, Léonie Egli, Jérémy Cros, Robin Rosset, Virgile Lecoultre, Roland Kreis, Chris Boesch, and et al. 2019. "Effects of Dietary Protein and Fat Content on Intrahepatocellular and Intramyocellular Lipids during a 6-Day Hypercaloric, High Sucrose Diet: A Randomized Controlled Trial in Normal Weight Healthy Subjects" Nutrients 11, no. 1: 209. https://doi.org/10.3390/nu11010209

APA Style

Surowska, A., Jegatheesan, P., Campos, V., Marques, A.-S., Egli, L., Cros, J., Rosset, R., Lecoultre, V., Kreis, R., Boesch, C., Pouymayou, B., Schneiter, P., & Tappy, L. (2019). Effects of Dietary Protein and Fat Content on Intrahepatocellular and Intramyocellular Lipids during a 6-Day Hypercaloric, High Sucrose Diet: A Randomized Controlled Trial in Normal Weight Healthy Subjects. Nutrients, 11(1), 209. https://doi.org/10.3390/nu11010209

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