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Open AccessReview

Effects of Caffeine on Myocardial Blood Flow: A Systematic Review

1
Center for Medical Imaging, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
2
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
3
HMC-Bronovo, Haaglanden Medisch Centrum, Department of Radiology, Haaglanden Medisch Centrum-Bronovo, 2597 AX The Hague, The Netherlands
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(8), 1083; https://doi.org/10.3390/nu10081083
Received: 6 July 2018 / Revised: 9 August 2018 / Accepted: 10 August 2018 / Published: 13 August 2018
(This article belongs to the Special Issue The Impact of Caffeine and Coffee on Human Health)
Background. Caffeine is one of the most widely consumed stimulants worldwide. It is a well-recognized antagonist of adenosine and a potential cause of false-negative functional measurements during vasodilator myocardial perfusion. The aim of this systematic review is to summarize the evidence regarding the effects of caffeine intake on functional measurements of myocardial perfusion in patients with suspected coronary artery disease. Pubmed, Web of Science, and Embase were searched using a predefined electronic search strategy. Participants—healthy subjects or patients with known or suspected CAD. Comparisons—recent caffeine intake versus no caffeine intake. Outcomes—measurements of functional myocardial perfusion. Study design—observational. Fourteen studies were deemed eligible for this systematic review. There was a wide range of variability in study design with varying imaging modalities, vasodilator agents, serum concentrations of caffeine, and primary outcome measurements. The available data indicate a significant influence of recent caffeine intake on cardiac perfusion measurements during adenosine and dipyridamole induced hyperemia. These effects have the potential to affect the clinical decision making by re-classification to different risk-categories. View Full-Text
Keywords: caffeine; myocardial perfusion; coronary artery disease; adenosine; regadenoson; dipyridamole caffeine; myocardial perfusion; coronary artery disease; adenosine; regadenoson; dipyridamole
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Van Dijk, R.; Ties, D.; Kuijpers, D.; Van der Harst, P.; Oudkerk, M. Effects of Caffeine on Myocardial Blood Flow: A Systematic Review. Nutrients 2018, 10, 1083.

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