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The Role of Genetics in Moderating the Inter-Individual Differences in the Ergogenicity of Caffeine
Review

Impact of Genetic Variability on Physiological Responses to Caffeine in Humans: A Systematic Review

1
Department of Movement Science, Chatham University, Pittsburgh, PA 15232, USA
2
FAME Laboratory, Department of Exercise Science, University of Thessaly, GR42100 Trikala, Greece
3
Department of Exercise Physiology, West Virginia University School of Medicine, West Virginia University, Morganton, WV 26506, USA
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(10), 1373; https://doi.org/10.3390/nu10101373
Received: 1 September 2018 / Revised: 21 September 2018 / Accepted: 23 September 2018 / Published: 25 September 2018
(This article belongs to the Special Issue The Impact of Caffeine and Coffee on Human Health)
Emerging research has demonstrated that genetic variation may impact physiological responses to caffeine consumption. The purpose of the present review was to systematically recognize how select single nucleotide polymorphisms (SNPs) impact habitual use of caffeine as well as the ergogenic and anxiogenic consequences of caffeine. Two databases (PubMed and EBSCO) were independently searched using the same algorithm. Selected studies involved human participants and met at least one of the following inclusion criteria: (a) genetic analysis of individuals who habitually consume caffeine; (b) genetic analysis of individuals who underwent measurements of physical performance with the consumption of caffeine; (c) genetic analysis of individuals who underwent measurements of mood with the consumption of caffeine. We included 26 studies (10 randomized controlled trials, five controlled trials, seven cross-sectional studies, three single-group interventional studies and one case-control study). Single nucleotide polymorphisms in or near the cytochrome P450 (CYP1A2) and aryl hydrocarbon receptor (AHR) genes were consistently associated with caffeine consumption. Several studies demonstrated that the anxiogenic consequences of caffeine differed across adenosine 2a receptor (ADORA2A) genotypes, and the studies that investigated the effects of genetic variation on the ergogenic benefit of caffeine reported equivocal findings (CYP1A2) or warrant replication (ADORA2A). View Full-Text
Keywords: polymorphism; anxiety; ergogenic; adenosine receptor; cytochrome P450; caffeine; pharmacogenomics polymorphism; anxiety; ergogenic; adenosine receptor; cytochrome P450; caffeine; pharmacogenomics
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MDPI and ACS Style

Fulton, J.L.; Dinas, P.C.; Carrillo, A.E.; Edsall, J.R.; Ryan, E.J.; Ryan, E.J. Impact of Genetic Variability on Physiological Responses to Caffeine in Humans: A Systematic Review. Nutrients 2018, 10, 1373. https://doi.org/10.3390/nu10101373

AMA Style

Fulton JL, Dinas PC, Carrillo AE, Edsall JR, Ryan EJ, Ryan EJ. Impact of Genetic Variability on Physiological Responses to Caffeine in Humans: A Systematic Review. Nutrients. 2018; 10(10):1373. https://doi.org/10.3390/nu10101373

Chicago/Turabian Style

Fulton, Jacob L., Petros C. Dinas, Andres E. Carrillo, Jason R. Edsall, Emily J. Ryan, and Edward J. Ryan 2018. "Impact of Genetic Variability on Physiological Responses to Caffeine in Humans: A Systematic Review" Nutrients 10, no. 10: 1373. https://doi.org/10.3390/nu10101373

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