Audiovestibular Disorders after COVID-19 Vaccine: Is There an Association?
, Federico Maria Gioacchini 2,†, Pasquale Viola 1,*, Alfonso Scarpa 3, Alessia Astorina 1, Massimo Re 2, Gianmarco Marcianò 4, Francesco Manti 5, Roberta Anzivino 6 and Giuseppe Chiarella 1
Round 1
Reviewer 1 Report
This study reviewed reports of audiovestibular symptoms after COVID-19 vaccination. It has timely significance. However, this manuscript has several points to modify.
1. First of all, to support the authors’ conclusion that there is no evidence of the association between COVID-19 vaccination and audiovestibular events, it could be better to cite the unclear association from reviewed papers more in Discussion.
2. English needs to be checked because there are many inappropriate divisions of paragraph, awkward expressions, misuse of punctuation marks and upper and lower cases, and grammatical errors.
3. In the main manuscript, several abbreviations were used without explanations at the first presentation.
4. In lines 55-57, it seems better to present specific COVID-19 vaccines (Pfizer, Astra-Zeneca, Moderna, Sinovac, etc) according to each type of COVID-19 vaccines.
5. It seems better to present the table which shows vertigo/dizziness as COVID-19 AEFI in addition, although it is difficult to identify individual patients’ characteristics in Di Mauro et al.’s report.
6. In lines 160-164, the description about Jeong et al.’s report is incorrect. Among 3 patients with SSNHL after COVID-19 vaccination, Patient 1 was female, and Patients 2 (hearing loss at low frequencies) and 3 were male.
7. In line 233, Jeong et al. -> Jeong.
8. In line 236, the authors do not -> the author did not.
9. In line 287, Covid-19 or Covid-19 -> COVID-19 or COVID-19 vaccination.
10. In line 293, hypnotize -> hypothesize.
Author Response
This study reviewed reports of audiovestibular symptoms after COVID-19 vaccination. It has timely significance. However, this manuscript has several points to modify.
- First of all, to support the authors’ conclusion that there is no evidence of the association between COVID-19 vaccination and audiovestibular events, it could be better to cite the unclear association from reviewed papers more in Discussion.
R: we have modified the discussion section and the conclusions section in order to accommodate this request
- English needs to be checked because there are many inappropriate divisions of paragraph, awkward expressions, misuse of punctuation marks and upper and lower cases, and grammatical errors.
R: the draft has been completely revised in accordance with this request, thank you
- In the main manuscript, several abbreviations were used without explanations at the first presentation.
R: We have changed the text to accommodate this request
- In lines 55-57, it seems better to present specific COVID-19 vaccines (Pfizer, Astra-Zeneca, Moderna, Sinovac, etc) according to each type of COVID-19 vaccines.
R: Thanks for the suggestion, we decided to mention the type of vaccine in the introduction and only later in the discussion associate each commercial product to the respective mechanism of action.
- It seems better to present the table which shows vertigo/dizziness as COVID-19 AEFI in addition, although it is difficult to identify individual patients’ characteristics in Di Mauro et al.’s report.
R: The data from the study by Di Mauro et al. they are difficult to systematize in a table and in any case would not add anything significant to the discussion, being a small sample and with many confounding factors.
- In lines 160-164, the description about Jeong et al.’s report is incorrect. Among 3 patients with SSNHL after COVID-19 vaccination, Patient 1 was female, and Patients 2 (hearing loss at low frequencies) and 3 were male.
R: The description of the cases has been modified to comply with the requirements of the reviewer
- In line 233, Jeong et al. -> Jeong.
R: Right! Modified
- In line 236, the authors do not -> the author did not.
R: modified, thank you for kind suggestion
- In line 287, Covid-19 or Covid-19 -> COVID-19 or COVID-19 vaccination.
R: modified, thanks!
- In line 293, hypnotize -> hypothesize.
R: done.
Reviewer 2 Report
Very nice review on a really interesting and important topic, Audiovestibular disorders following Covid-19 vaccine . Very good introduction, well-described methods, complete and detailed results. Authors provided a well structuded and informative discussion. I am convinced that this article will be warmly embraced by the journal's readers. I totally suggest publication.
Author Response
Very nice review on a really interesting and important topic, Audiovestibular disorders following Covid-19 vaccine . Very good introduction, well-described methods, complete and detailed results. Authors provided a well structuded and informative discussion. I am convinced that this article will be warmly embraced by the journal's readers. I totally suggest publication.
R: We thank you for the nice words of appreciation, our effort has been directed to the disclosure of possible adverse events related to vaccines, avoiding arousing further distrust of a tool that has proved decisive in the fight against the virus.
Reviewer 3 Report
Good topic, hot and interesting!
Perhaps the name of the artice can be cange! as a question!
I recommend a few modification.
Double check the English.
Please describe the abbreviations when you use them for the first time.
The paragraph between row 183 and 190 is extremely hard to read, rewrite please.
Table 1 is hard to read! Maximize writing!
I think that you need three short conclusions!
My recommendation is to focus on 3 short conclusions!
Author Response
Good topic, hot and interesting!
Perhaps the name of the artice can be cange! as a question!
R: Modified
I recommend a few modification.
Double check the English.
R: we corrected some errors, thanks.
Please describe the abbreviations when you use them for the first time.
R: We revised the text, identified unexplained abbreviations, as well as terms that needed abbreviation
The paragraph between row 183 and 190 is extremely hard to read, rewrite please.
R: The description of this particular case has been revised and simplified
Table 1 is hard to read! Maximize writing!
R: Table 1 has been simplified following the recommendations
I think that you need three short conclusions!
My recommendation is to focus on 3 short conclusions!
R: We have rewritten the conclusion of the article, aiming at conciseness. Thank you!
Round 2
Reviewer 1 Report
The manuscript has been improved after authors’ revision. However, although the authors checked English in the manuscript, there are still unclear expressions, inappropriate division of paragraphs, and grammatical errors. It is better to check English in the manuscript again entirely.
1. In line 238, the authors -> the author.
Author Response
Dear Reviewer, thanks for the comments.
We have extensively revised the text regarding grammar, paragraph fluency and language style.
Best Regards;
The authors
