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Viruses 2010, 2(5), 1069-1105;

HIV-1 Entry, Inhibitors, and Resistance

Department of Molecular Biology and Microbiology and Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA
Author to whom correspondence should be addressed.
Received: 23 February 2010 / Revised: 16 April 2010 / Accepted: 18 April 2010 / Published: 29 April 2010
(This article belongs to the Special Issue HIV Drug Resistance 2010)
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Entry inhibitors represent a new class of antiretroviral agents for the treatment of infection with HIV-1. While resistance to other HIV drug classes has been well described, resistance to this new class is still ill defined despite considerable clinical use. Several potential mechanisms have been proposed: tropism switching (utilization of CXCR4 instead of CCR5 for entry), increased affinity for the coreceptor, increased rate of virus entry into host cells, and utilization of inhibitor-bound receptor for entry. In this review we will address the development of attachment, fusion, and coreceptor entry inhibitors and explore recent studies describing potential mechanisms of resistance. View Full-Text
Keywords: HIV-1; envelope; gp120; V3 loop; gp41; CCR5; maraviroc; vicriviroc HIV-1; envelope; gp120; V3 loop; gp41; CCR5; maraviroc; vicriviroc

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Lobritz, M.A.; Ratcliff, A.N.; Arts, E.J. HIV-1 Entry, Inhibitors, and Resistance. Viruses 2010, 2, 1069-1105.

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