Viral Loads and Disease Severity in Children with Rhinovirus-Associated Illnesses
, Katherine Moyer 2, Isabel Benavente-Fernández 3,4,5, Amy L. Leber 6, Octavio Ramilo 7 and Asuncion Mejias 7,8,*Round 1
Reviewer 1 Report
- Suggestions to Author/s
1. Dear dr.Asuncion Mejias, as a selected reviewer, I made a promt check of your article:«Viral loads and disease severity in children with rhinovirus associated illnesses«, and found it:(x) Excellent, accept the submission (5). I will suggest to the editor to include it into the Journal as it is, as soon as possible!
2. Due to the check of your article, I found some minor mistakes in the text, and I kindly ask you to correct them as follows:
Line no: Correction ( Add or Remove)
20 Dell: presenting
21 Add: , Dell: is
21 Dell: we Add: So, we
31 Add: the
42 Add: ,
43 Add :
46 Add: largely
58 Dell: presenting
59 Dell: presenting
67 Add: were
88 Dell: in Add: into
125 Add: as
129 Dell: ,
131 Add: were
138 On Fig.1 Dell: H
170 Add: in Add: the
173 Dell: represents Add: show
175 Dell: represents Add: show
215 Add: the
216 Add: the Add: any
240 Dell: in Add: with
280 Add: any
307 Dell: has been Add: was
310 Dell: representing
319 Dell: has been Add: was
324 Dell: P
351 Dell: have been Add: were
365 Dell: has
404 Dell: and have Add: has
405 Dell: has
Comments for author File: 
Comments.pdf
Author Response
We thank the reviewer very much for the comments. We have now corrected all the typographical errors listed, and have also replaced Figure 1 with a new figure that does not have the word H as part of rhinovirus (RV instead of HRV).
Reviewer 2 Report
This manuscript describes a large cohort of children that was tested for several viral infections, although rhinoviruses are the focus of this study. The novelty of the study is in the identification of children that were RV+, but did not have classically associated RV symptoms, and a comparison of viral loads, incidence of bacterial coinfections, and disease severity.
The manuscript is very well written and easy to read, and provides a thorough analysis of comprehensive data sets.
The labeling in Figure 2 is in correct. The incidental should be gray and the compatible should be black according to the data in the text and the figure caption for this figure. Please double check as this is a major error.
Minor typos:
Line 51: join to joint
Line 150: of children
Line 384: in played?
Author Response
We thank the reviewer very much for the comments. We have now corrected all the typographical errors listed, and have also replaced Figure 2 with a new figure that has now the correct labeling. We do apologize for the oversight.
