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Detection of Intracellular Gold Nanoparticles: An Overview

Consiglio Nazionale delle Ricerche, Istituto di Biofisica, CNR-IBF, via Moruzzi 1, 56124 Pisa, Italy
Materials 2018, 11(6), 882; https://doi.org/10.3390/ma11060882
Received: 16 April 2018 / Revised: 14 May 2018 / Accepted: 21 May 2018 / Published: 24 May 2018
(This article belongs to the Special Issue Photothermal Therapy of Nanomaterials)
Photothermal therapy (PTT) takes advantage of unique properties of gold nanoparticles (AuNPs) (nanospheres, nanoshells (AuNSs), nanorods (AuNRs)) to destroy cancer cells or tumor tissues. This is made possible thanks principally to both to the so-called near-infrared biological transparency window, characterized by wavelengths falling in the range 700–1100 nm, where light has its maximum depth of penetration in tissue, and to the efficiency of cellular uptake mechanisms of AuNPs. Consequently, the possible identification of intracellular AuNPs plays a key role for estimating the effectiveness of PTT treatments. Here, we review the recognized detection techniques of such intracellular probes with a special emphasis to the exploitation of near-infrared biological transparency window. View Full-Text
Keywords: gold nanoparticles; cellular uptake mechanism; Dark Field Microscopy; Surface-enhanced Raman spectroscopy; Scanning Near-Optical Microscopy gold nanoparticles; cellular uptake mechanism; Dark Field Microscopy; Surface-enhanced Raman spectroscopy; Scanning Near-Optical Microscopy
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D’Acunto, M. Detection of Intracellular Gold Nanoparticles: An Overview. Materials 2018, 11, 882.

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