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Article

A Semimetal-Like Molybdenum Carbide Quantum Dots Photoacoustic Imaging and Photothermal Agent with High Photothermal Conversion Efficiency

by 1,2, 1,2,* and 1,2,*
1
Research Center for Biomedical and Health Science, Anhui Science and Technology University, Fengyang 233100, China
2
Research Center for Bioengineering and Sensing Technology, School of Chemistry and Bioengineering, University of Science & Technology Beijing, Beijing 100083, China
*
Authors to whom correspondence should be addressed.
Materials 2018, 11(9), 1776; https://doi.org/10.3390/ma11091776
Received: 15 August 2018 / Revised: 6 September 2018 / Accepted: 13 September 2018 / Published: 19 September 2018
(This article belongs to the Special Issue Photothermal Therapy of Nanomaterials)
Theranostic platforms integrating imaging diagnostic and therapeutic interventions into a single nanoplatform have attracted considerable attention for cancer-individualized therapies. However, their uncertain stability, complex pharmacokinetics, and intrinsic toxicology of multiple components hinder their practical application in clinical research. In this paper, stable and high-concentration molybdenum carbide quantum dots (Mo2C QDs) with a diameter of approximately 6 nm and a topographic height of about 1.5 nm were synthesized using a facile sonication-assisted liquid-phase exfoliation approach. The prepared Mo2C QDs exhibited a strong near-infrared (NIR) absorbance with a high molar extinction coefficient of 4.424 Lg−1cm−1 at 808 nm, a high photothermal conversion efficiency of 42.9%, and showed excellent performance on photoacoustic imaging. The Mo2C QDs had high stability and highly biocompatibility, with low cytotoxicity. Under NIR irradiation, a remarkable in vitro and in vivo therapeutic effect was obtained. Such a stable and biocompatible all-in-one theranostic nanoagent generated by facile synthesis that combines promising imaging guidance and effective tumor ablation properties may hold great potential for theranostic nanomedicine. View Full-Text
Keywords: molybdenum carbide; quantum dots; theranostic nanomedicines; dual-modal imaging; photothermal therapy molybdenum carbide; quantum dots; theranostic nanomedicines; dual-modal imaging; photothermal therapy
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MDPI and ACS Style

Dai, W.; Dong, H.; Zhang, X. A Semimetal-Like Molybdenum Carbide Quantum Dots Photoacoustic Imaging and Photothermal Agent with High Photothermal Conversion Efficiency. Materials 2018, 11, 1776. https://doi.org/10.3390/ma11091776

AMA Style

Dai W, Dong H, Zhang X. A Semimetal-Like Molybdenum Carbide Quantum Dots Photoacoustic Imaging and Photothermal Agent with High Photothermal Conversion Efficiency. Materials. 2018; 11(9):1776. https://doi.org/10.3390/ma11091776

Chicago/Turabian Style

Dai, Wenhao, Haifeng Dong, and Xueji Zhang. 2018. "A Semimetal-Like Molybdenum Carbide Quantum Dots Photoacoustic Imaging and Photothermal Agent with High Photothermal Conversion Efficiency" Materials 11, no. 9: 1776. https://doi.org/10.3390/ma11091776

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