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Review

The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review

1
School of Health and Human Performance, Dalhousie University, Halifax, NS B3H4R2, Canada
2
Beatrice Hunter Cancer Research Institute, Halifax, NS B3H4R2, Canada
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Faculty of Health, Dalhousie University, Halifax, NS B3H4R2, Canada
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Department of Pediatrics, IWK Health, Halifax, NS B3K6R8, Canada
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Department of Medicine, Division of Cardiology, Nova Scotia Health, Halifax, NS B3H3A7, Canada
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Department of Pharmacology, Dalhousie University, Halifax, NS B3H4R2, Canada
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Department of Medicine, Division of Medical Oncology, Nova Scotia Health, Halifax, NS B3H4R2, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2022, 29(9), 6350-6363; https://doi.org/10.3390/curroncol29090500
Received: 25 July 2022 / Revised: 22 August 2022 / Accepted: 22 August 2022 / Published: 3 September 2022
Childhood and adolescent cancer survivors are disproportionately more likely to develop cardiovascular diseases from the late effects of cardiotoxic therapies (e.g., anthracycline-based chemotherapy and chest-directed radiotherapy). Currently, dexrazoxane is the only approved drug for preventing cancer treatment-related cardiac damage. While animal models highlight the beneficial effects of exercise cancer treatment-related cardiac dysfunction, few clinical studies have been conducted. Thus, the objective of this scoping review was to explore the designs and impact of exercise-based interventions for managing cancer treatment-related cardiac dysfunction in childhood and adolescent cancer survivors. Reviewers used Joanna Briggs Institute’s methodology to identify relevant literature. Then, 4616 studies were screened, and three reviewers extracted relevant data from six reports. Reviewers found that exercise interventions to prevent cancer treatment-related cardiac dysfunction in childhood and adolescent cancer survivors vary regarding frequency, intensity, time, and type of exercise intervention. Further, the review suggests that exercise promotes positive effects on managing cancer treatment-related cardiac dysfunction across numerous indices of heart health. However, the few clinical studies employing exercise interventions for childhood and adolescent cancer survivors highlight the necessity for more research in this area. View Full-Text
Keywords: exercise; cardiotoxicity; cancer; cancer survivor; pediatric; adolescent exercise; cardiotoxicity; cancer; cancer survivor; pediatric; adolescent
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MDPI and ACS Style

Kendall, S.J.; Langley, J.E.; Aghdam, M.; Crooks, B.N.; Giacomantonio, N.; Heinze-Milne, S.; Johnston, W.J.; Keats, M.R.; Mulvagh, S.L.; Grandy, S.A. The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review. Curr. Oncol. 2022, 29, 6350-6363. https://doi.org/10.3390/curroncol29090500

AMA Style

Kendall SJ, Langley JE, Aghdam M, Crooks BN, Giacomantonio N, Heinze-Milne S, Johnston WJ, Keats MR, Mulvagh SL, Grandy SA. The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review. Current Oncology. 2022; 29(9):6350-6363. https://doi.org/10.3390/curroncol29090500

Chicago/Turabian Style

Kendall, Stephanie J., Jodi E. Langley, Mohsen Aghdam, Bruce N. Crooks, Nicholas Giacomantonio, Stefan Heinze-Milne, Will J. Johnston, Melanie R. Keats, Sharon L. Mulvagh, and Scott A. Grandy. 2022. "The Impact of Exercise on Cardiotoxicity in Pediatric and Adolescent Cancer Survivors: A Scoping Review" Current Oncology 29, no. 9: 6350-6363. https://doi.org/10.3390/curroncol29090500

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