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Current Oncology
Volume 28
Issue 6
10.3390/curroncol28060424
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Article

Changes in Brain Energy and Membrane Metabolism in Glioblastoma following Chemoradiation

by
Astrid Ellen Grams
1,2,†,
Stephanie Mangesius
1,2,†,
Ruth Steiger
1,2,*,
Ivan Radovic
1,2,
Andreas Rietzler
1,2,
Lisa Maria Walchhofer
3,
Malik Galijašević
1,2,
Julian Mangesius
4,
Martha Nowosielski
5,
Christian Franz Freyschlag
6,
Johannes Kerschbaumer
6 and
Elke Ruth Gizewski
1,2
1
Department of Neuroradiology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
2
Neuroimaging Core Facility, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
3
Department of Radiology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
4
Department of Radiation Oncology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
5
Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
6
Department of Neurosurgery, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
*
Author to whom correspondence should be addressed.
†
Contributed equally, shared first author.
Curr. Oncol. 2021, 28(6), 5041-5053; https://doi.org/10.3390/curroncol28060424
Submission received: 23 September 2021 / Revised: 24 November 2021 / Accepted: 26 November 2021 / Published: 1 December 2021
(This article belongs to the Special Issue Recent Advancements in the Surgical Treatment of Brain Tumors)
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Abstract

Brain parenchyma infiltration with glioblastoma (GB) cannot be entirely visualized by conventional magnetic resonance imaging (MRI). The aim of this study was to investigate changes in the energy and membrane metabolism measured with phosphorous MR spectroscopy (31P-MRS) in the presumably “normal-appearing” brain following chemoradiation therapy (CRT) in GB patients in comparison to healthy controls. Twenty (seven female, thirteen male) GB patients underwent a 31P-MRS scan prior to surgery (baseline) and after three months of standard CRT (follow-up examination. The regions of interest “contrast-enhancing (CE) tumor” (if present), “adjacent to the (former) tumor”, “ipsilateral distant” hemisphere, and “contralateral” hemisphere were compared, differentiating between patients with stable (SD) and progressive disease (PD). Metabolite ratios PCr/ATP, Pi/ATP, PCr/Pi, PME/PDE, PME/PCr, and PDE/ATP were investigated. In PD, energy and membrane metabolism in CE tumor areas have a tendency to “normalize” under therapy. In different “normal-appearing” brain areas of GB patients, the energy and membrane metabolism either “normalized” or were “disturbed”, in comparison to baseline or controls. Differences were also detected between patients with SD and PD. 31P-MRS might contribute as an additional imaging biomarker for outcome measurement, which remains to be investigated in a larger cohort.
Keywords: phosphorous magnetic resonance spectroscopy (31P-MRS); cerebral energy metabolism; ATP; glioblastoma; chemoradiation; normal-appearing brain tissue; tumor infiltration phosphorous magnetic resonance spectroscopy (31P-MRS); cerebral energy metabolism; ATP; glioblastoma; chemoradiation; normal-appearing brain tissue; tumor infiltration

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MDPI and ACS Style

Grams, A.E.; Mangesius, S.; Steiger, R.; Radovic, I.; Rietzler, A.; Walchhofer, L.M.; Galijašević, M.; Mangesius, J.; Nowosielski, M.; Freyschlag, C.F.; et al. Changes in Brain Energy and Membrane Metabolism in Glioblastoma following Chemoradiation. Curr. Oncol. 2021, 28, 5041-5053. https://doi.org/10.3390/curroncol28060424

AMA Style

Grams AE, Mangesius S, Steiger R, Radovic I, Rietzler A, Walchhofer LM, Galijašević M, Mangesius J, Nowosielski M, Freyschlag CF, et al. Changes in Brain Energy and Membrane Metabolism in Glioblastoma following Chemoradiation. Current Oncology. 2021; 28(6):5041-5053. https://doi.org/10.3390/curroncol28060424

Chicago/Turabian Style

Grams, Astrid Ellen, Stephanie Mangesius, Ruth Steiger, Ivan Radovic, Andreas Rietzler, Lisa Maria Walchhofer, Malik Galijašević, Julian Mangesius, Martha Nowosielski, Christian Franz Freyschlag, and et al. 2021. "Changes in Brain Energy and Membrane Metabolism in Glioblastoma following Chemoradiation" Current Oncology 28, no. 6: 5041-5053. https://doi.org/10.3390/curroncol28060424

APA Style

Grams, A. E., Mangesius, S., Steiger, R., Radovic, I., Rietzler, A., Walchhofer, L. M., Galijašević, M., Mangesius, J., Nowosielski, M., Freyschlag, C. F., Kerschbaumer, J., & Gizewski, E. R. (2021). Changes in Brain Energy and Membrane Metabolism in Glioblastoma following Chemoradiation. Current Oncology, 28(6), 5041-5053. https://doi.org/10.3390/curroncol28060424

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