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Marine Drugs, Volume 2, Issue 1

March 2004 - 5 articles

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Articles (5)

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Article

24 Citations

9,325 Views

7 Pages

An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene-15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity

Hesham Fahmy,
Sherief I. Khalifa,
Takao Konoshima and
Jordan K. Zjawiony

Mar. Drugs2004, 2(1), 1-7;https://doi.org/10.3390/md201001

25 February 2004

An effective method for the synthesis of 7,8-epoxy-1,3,11-cembratriene-15R(α), 16-diol and its in vitro Epstein-Barr Virus Early Antigen (EBV-EA) Activation Chemopreventive Assay are reported. This semisynthetic product is a new cembranoid with a pot...

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Article

14 Citations

11,223 Views

6 Pages

Antifungal Activity of (+)-Curcuphenol, a Metabolite from the Marine Sponge Didiscus oxeata

Helena Gaspar,
Sonia Savluchinske Feio,
Ana Isabel Rodrigues and
Rob Van Soest

Mar. Drugs2004, 2(1), 8-13;https://doi.org/10.3390/md201008

25 February 2004

The antifungal activity of the sesquiterpenoids (+)-curcuphenol and (+)-curcudiol isolated from the Caribbean sponge Didiscus oxeata was evaluated against several filamentous fungi.

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Review

166 Citations

18,918 Views

16 Pages

New Marine Derived Anticancer Therapeutics ─ A Journey from the Sea to Clinical Trials

J. Jimeno,
G. Faircloth,
JM Fernández Sousa-Faro,
P. Scheuer and
K. Rinehart

Mar. Drugs2004, 2(1), 14-29;https://doi.org/10.3390/md201014

25 February 2004

Nature has been instrumental as a source for therapeutics. Despite the fact that we live in an oceanic planet, a number of technical factors have historically hampered the evolution of a marine-based chamanic medicine. With the implementation of scub...

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Article

5 Citations

9,845 Views

9 Pages

Identification and Biological Characterization of Angiogenic and Tumor Growth Inhibitors derived from Sinica cetorhinus maximum Cartilage

Binghua Jiao,
Jianhe Chen,
Weimin Miao,
Lianghua Wang,
Yuping Zhu and
Huinan Miao

Mar. Drugs2004, 2(1), 30-38;https://doi.org/10.3390/md201030

25 February 2004

Shark (Sinica cetorhinus maximum) cartilage was extracted in 1 mol/L Gu-HCl guanidine. Two purified active proteins with apparent molecular weights of 15.2x103 Da and 8.0×103 Da (designated as Sp15 and Sp8, respectively) were obtained through ultrafi...

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Article

77 Citations

14,377 Views

16 Pages

Bioactive Alkaloids from the Sea: A Review

Makoto Kuramoto,
Hirokazu Arimoto and
Daisuke Uemura

Mar. Drugs2004, 2(1), 39-54;https://doi.org/10.3390/md201039

25 February 2004

In our ongoing search for bioactive substances from marine organisms, novel alkaloids have been isolated. Pinnatoxins and pinnamine, potent shellfish poisons, were purified from the Okinawan bivalve Pinna muricata. Pinnatoxins activate Ca2+ channels....

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