Headache in the Emergency Department: A Multicenter Observational Study from Singapore

Round 1

Reviewer 1 Report

Dear Authors

Thanks for this observational study which was aim to describe the clinical features, investigations, diagnosis, treatment, and outcome of nontraumatic headache in adults who present to EDs in Singapore with headache. The 579 patient admitted to the study at 4 weeks. The 44% of them was primary benign headache and the ct scan performed to 191 patient. There were 20% abnormalities. Migraine was the most frequent primary headache in Singapore ED’s. Before publication references should be written as journal rules.

Author Response

We thank Reviewer 1 for the comments and shall work with the copy editing team to ensure the format of references are in line with journal rules and style.

Reviewer 2 Report

Thank you for the opportunity to be among the first to read your contribution.

I have no negative comments on the contribution, only good ones. The topic is current and interesting, the methodology is appropriately set and the results and conclusions are scientifically sound. This contribution is written in accordance with the instructions. 

I would only ask that, in the interests of the legitimacy of the results, you provide information about the registration of the research or the permits of the institutions where the research took place and in what way the patients gave their consent to be included in this research.

Author Response

We thank Reviewer 2 for the encouraging comments. Description of the ethics approval and waiver of informed consent are stated from lines 286-290.

We have added the trial registration information in lines 291-292:

Clinical Trials Register: The parent study was registered with the Australia and New Zealand Clinical Trials Register (trial number 376695).