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Article

SARS-CoV-2 Seroprevalence in Western Romania, March to June 2021

by
Tudor Rares Olariu
1,2,3,*,
Alina Cristiana Craciun
2,
Daliborca Cristina Vlad
4,5,
Victor Dumitrascu
4,5,
Iosif Marincu
1 and
Maria Alina Lupu
1,3,6
1
Discipline of Parasitology, Department of Infectious Disease, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
2
Clinical Laboratory, Municipal Clinical Emergency Teaching Hospital, 300254 Timisoara, Romania
3
Center for Diagnosis and Study of Parasitic Diseases, Department of Infectious Disease, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
4
Department of Biochemistry and Pharmacology, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania
5
Clinical Laboratory, County Clinical Emergency Teaching Hospital, 300723 Timisoara, Romania
6
Clinical Laboratory, Institute of Cardiovascular Diseases, 300310 Timisoara, Romania
*
Author to whom correspondence should be addressed.
Medicina 2022, 58(1), 35; https://doi.org/10.3390/medicina58010035
Submission received: 1 December 2021 / Revised: 20 December 2021 / Accepted: 23 December 2021 / Published: 26 December 2021
(This article belongs to the Special Issue Infections and Infectious Diseases: Epidemiology, Mechanisms of Infection and Treatment Options)
Versions Notes

Abstract

Background and Objectives: The extent of SARS-CoV-2 infection among a population may be assessed by the presence of serum SARS-CoV-2 antibodies, which indicates previous exposure. The aim of this study was to determine the seroprevalence of SARS-CoV-2 infection in the adult population from Western Romania. Materials and Methods: Samples of 2443 consecutive individuals, referred for routine laboratory investigations, were tested for SARS-CoV-2 antibodies using the Elecsys immunoassay that targets the nucleocapsid protein, for identifying the presence of the total antibodies against SARS-CoV-2. Results: The overall SARS-CoV-2 seroprevalence was 45.60%. SARS-CoV-2 seroprevalence was significantly higher in age group 30–49 years (53.94%) compared to age groups 50–69 years (43.53%) and 70–91 years (30.79%) (p < 0.001, p < 0.001, respectively). No significant difference in seroprevalence was observed between females (44.83%) and males (47.05%). Conclusions: Our data revealed a high seroprevalence of SARS-CoV-2 infection in the adult population from Western Romania and indicate the rapid and significant spread of the virus. The estimated prevalence of 45.60% was 6 times higher than the rate of confirmed COVID-19 cases reported in the study area. This indicates the magnitude of virus transmission in the community.
Keywords: SARS-CoV-2; antibodies; COVID-19; seroprevalence; epidemiology; Romania SARS-CoV-2; antibodies; COVID-19; seroprevalence; epidemiology; Romania

Share and Cite

MDPI and ACS Style

Olariu, T.R.; Craciun, A.C.; Vlad, D.C.; Dumitrascu, V.; Marincu, I.; Lupu, M.A. SARS-CoV-2 Seroprevalence in Western Romania, March to June 2021. Medicina 2022, 58, 35. https://doi.org/10.3390/medicina58010035

AMA Style

Olariu TR, Craciun AC, Vlad DC, Dumitrascu V, Marincu I, Lupu MA. SARS-CoV-2 Seroprevalence in Western Romania, March to June 2021. Medicina. 2022; 58(1):35. https://doi.org/10.3390/medicina58010035

Chicago/Turabian Style

Olariu, Tudor Rares, Alina Cristiana Craciun, Daliborca Cristina Vlad, Victor Dumitrascu, Iosif Marincu, and Maria Alina Lupu. 2022. "SARS-CoV-2 Seroprevalence in Western Romania, March to June 2021" Medicina 58, no. 1: 35. https://doi.org/10.3390/medicina58010035

APA Style

Olariu, T. R., Craciun, A. C., Vlad, D. C., Dumitrascu, V., Marincu, I., & Lupu, M. A. (2022). SARS-CoV-2 Seroprevalence in Western Romania, March to June 2021. Medicina, 58(1), 35. https://doi.org/10.3390/medicina58010035

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