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Review

Zebrafish as a Screening Model to Study the Single and Joint Effects of Antibiotics

1
Marine Biological Station “Prof. dr. I. Borcea”, “Alexandru Ioan Cuza” University of Iasi, Nicolae Titulescu Street, No. 163, 9007018 Agigea, Romania
2
Department of Exact and Natural Sciences, Institute of Interdisciplinary Research, “Alexandru Ioan Cuza” University of Iasi, 11 Carol I, 700506 Iasi, Romania
3
Integrated Center of Environmental Science Studies in the North Eastern Region (CERNESIM), “Alexandru Ioan Cuza” University of Iasi, 11 Carol I, 700506 Iasi, Romania
4
Department of Horticultural Technologies, “Ion Ionescu de la Brad” University of Agricultural Sciences and Veterinary Medicine, 700440 Iasi, Romania
5
Department of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University of Iasi, B-dul Carol I, 700505 Iasi, Romania
6
Doctoral School of Geosciences, Faculty of Geography-Geology, “Alexandru Ioan Cuza” University of Iasi, B-dul Carol I, 700505 Iasi, Romania
7
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno, d’Alcontres, 31 98166 S. Agata-Messina, Italy
*
Authors to whom correspondence should be addressed.
This paper is dedicated to the memory of Stefan-Adrian Strungaru, colleague, researcher and friend, who prematurely passed away in April 2021.
These authors contributed equally.
Academic Editors: Yuhei Nishimura and Martin Distel
Pharmaceuticals 2021, 14(6), 578; https://doi.org/10.3390/ph14060578
Received: 26 May 2021 / Revised: 11 June 2021 / Accepted: 12 June 2021 / Published: 17 June 2021
(This article belongs to the Special Issue Zebrafish as a Powerful Tool for Drug Discovery 2021)
The overuse of antibiotics combined with the limitation of wastewater facilities has resulted in drug residue accumulation in the natural environment. Thus, in recent years, the presence of antibiotic residues in the environment has raised concerns over the potential harmful effects on ecosystems and human health. The in vivo studies represent an essential step to study the potential impact induced by pharmaceutical exposure. Due to the limitations of traditional vertebrate model systems, zebrafish (Danio rerio) has recently emerged as a promising animal model to study the toxic effects of drugs and their therapeutic efficacy. The present review summarizes the recent advances made on the toxicity of seven representative classes of antibiotics, namely aminoglycosides, β-lactams, macrolides, quinolones, sulfonamides, tetracyclines and polyether antibiotics, in zebrafish, as well as the combined effects of antibiotic mixtures, to date. Despite a significant amount of the literature describing the impact of single antibiotic exposure, little information exists on the effects of antibiotic mixtures using zebrafish as an animal model. Most of the research papers on this topic have focused on antibiotic toxicity in zebrafish across different developmental stages rather than on their efficacy assessment. View Full-Text
Keywords: zebrafish; antibiotics; aquatic environment; toxicity; combined effects zebrafish; antibiotics; aquatic environment; toxicity; combined effects
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MDPI and ACS Style

Jijie, R.; Mihalache, G.; Balmus, I.-M.; Strungaru, S.-A.; Baltag, E.S.; Ciobica, A.; Nicoara, M.; Faggio, C. Zebrafish as a Screening Model to Study the Single and Joint Effects of Antibiotics . Pharmaceuticals 2021, 14, 578. https://doi.org/10.3390/ph14060578

AMA Style

Jijie R, Mihalache G, Balmus I-M, Strungaru S-A, Baltag ES, Ciobica A, Nicoara M, Faggio C. Zebrafish as a Screening Model to Study the Single and Joint Effects of Antibiotics . Pharmaceuticals. 2021; 14(6):578. https://doi.org/10.3390/ph14060578

Chicago/Turabian Style

Jijie, Roxana, Gabriela Mihalache, Ioana-Miruna Balmus, Stefan-Adrian Strungaru, Emanuel S. Baltag, Alin Ciobica, Mircea Nicoara, and Caterina Faggio. 2021. "Zebrafish as a Screening Model to Study the Single and Joint Effects of Antibiotics " Pharmaceuticals 14, no. 6: 578. https://doi.org/10.3390/ph14060578

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