Next Article in Journal
Natural Compounds and Derivatives as Ser/Thr Protein Kinase Modulators and Inhibitors
Next Article in Special Issue
L-Ferritin: One Gene, Five Diseases; from Hereditary Hyperferritinemia to Hypoferritinemia—Report of New Cases
Previous Article in Journal
Development of [131I]I-EOE-TPZ and [131I]I-EOE-TPZMO: Novel Tirapazamine (TPZ)-Based Radioiodinated Pharmaceuticals for Application in Theranostic Management of Hypoxia
Previous Article in Special Issue
Iron Regulation: Macrophages in Control
Open AccessReview

Iron Homeostasis in the Lungs—A Balance between Health and Disease

by Joana Neves 1,2,†, Thomas Haider 3,4,†, Max Gassmann 3,*,‡ and Martina U. Muckenthaler 1,2,5,*,‡
1
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, 69120 Heidelberg, Germany
2
Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, 69120 Heidelberg, Germany
3
Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, 8057 Zurich, Switzerland
4
Department of Cardiology, University Heart Center Zurich, University Hospital Zurich, 8091 Zurich, Switzerland
5
Molecular Medicine Partnership Unit, University of Heidelberg, 69120 Heidelberg, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally and share first-authorship.
These authors contributed equally and share the senior authorship.
Pharmaceuticals 2019, 12(1), 5; https://doi.org/10.3390/ph12010005
Received: 20 November 2018 / Revised: 23 December 2018 / Accepted: 25 December 2018 / Published: 1 January 2019
(This article belongs to the Special Issue Iron as Therapeutic Targets in Human Diseases)
A strong mechanistic link between the regulation of iron homeostasis and oxygen sensing is evident in the lung, where both systems must be properly controlled to maintain lung function. Imbalances in pulmonary iron homeostasis are frequently associated with respiratory diseases, such as chronic obstructive pulmonary disease and with lung cancer. However, the underlying mechanisms causing alterations in iron levels and the involvement of iron in the development of lung disorders are incompletely understood. Here, we review current knowledge about the regulation of pulmonary iron homeostasis, its functional importance, and the link between dysregulated iron levels and lung diseases. Gaining greater knowledge on how iron contributes to the pathogenesis of these diseases holds promise for future iron-related therapeutic strategies. View Full-Text
Keywords: iron homeostasis; lung diseases; oxygen sensing; hypoxia iron homeostasis; lung diseases; oxygen sensing; hypoxia
Show Figures

Figure 1

MDPI and ACS Style

Neves, J.; Haider, T.; Gassmann, M.; Muckenthaler, M.U. Iron Homeostasis in the Lungs—A Balance between Health and Disease. Pharmaceuticals 2019, 12, 5.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop