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Pharmaceuticals 2019, 12(1), 5; https://doi.org/10.3390/ph12010005

Iron Homeostasis in the Lungs—A Balance between Health and Disease

1,2,†
,
3,4,†
,
3,*,‡
and
1,2,5,*,‡
1
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, 69120 Heidelberg, Germany
2
Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, 69120 Heidelberg, Germany
3
Institute of Veterinary Physiology, Vetsuisse Faculty, and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, 8057 Zurich, Switzerland
4
Department of Cardiology, University Heart Center Zurich, University Hospital Zurich, 8091 Zurich, Switzerland
5
Molecular Medicine Partnership Unit, University of Heidelberg, 69120 Heidelberg, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally and share first-authorship.
These authors contributed equally and share the senior authorship.
Received: 20 November 2018 / Revised: 23 December 2018 / Accepted: 25 December 2018 / Published: 1 January 2019
(This article belongs to the Special Issue Iron as Therapeutic Targets in Human Diseases)
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Abstract

A strong mechanistic link between the regulation of iron homeostasis and oxygen sensing is evident in the lung, where both systems must be properly controlled to maintain lung function. Imbalances in pulmonary iron homeostasis are frequently associated with respiratory diseases, such as chronic obstructive pulmonary disease and with lung cancer. However, the underlying mechanisms causing alterations in iron levels and the involvement of iron in the development of lung disorders are incompletely understood. Here, we review current knowledge about the regulation of pulmonary iron homeostasis, its functional importance, and the link between dysregulated iron levels and lung diseases. Gaining greater knowledge on how iron contributes to the pathogenesis of these diseases holds promise for future iron-related therapeutic strategies. View Full-Text
Keywords: iron homeostasis; lung diseases; oxygen sensing; hypoxia iron homeostasis; lung diseases; oxygen sensing; hypoxia
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Neves, J.; Haider, T.; Gassmann, M.; Muckenthaler, M.U. Iron Homeostasis in the Lungs—A Balance between Health and Disease. Pharmaceuticals 2019, 12, 5.

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