(Z)-N-Carbamoyl-4-hydroxy-4-(4-methoxyphenyl)-2-oxobut-3-enamide

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

Maslivets et al. describe synthesis of one example of the imidazolidine class of compounds. Its synthesis proceeded uneventfully providing the desired product.

Comments

1. A yield of each reaction step should be added into the Schemes 1 and 2, as well as to the text.

2. MS and IR data are missing for compound 4. 

3. The prepared compound structurally differs from those dispayed in Figure 1. Hence, the crucial issue is: why the synthesis has been carried out at all? Is the prepared compound a potential intemediate for a preparation of more complex substance? The purpose of the synthesis should be specified.

Author Response

Comments 1. A yield of each reaction step should be added into the Schemes 1 and 2, as well as to the text.

Response 1: Thank you for pointing this out. We added these data to the manuscript (Scheme 2).

 

 

 

Comments 2. MS and IR data are missing for compound 4. 

Response 2: Compound 4 is a cyclic form of the title compound. We observed it in NMRs but we did not succeed to isolate it as a single substance. That’s why we added only NMRs for compound 4 to the manuscript.

 

 

 

Comments 3. The prepared compound structurally differs from those dispayed in Figure 1. Hence, the crucial issue is: why the synthesis has been carried out at all? Is the prepared compound a potential intemediate for a preparation of more complex substance? The purpose of the synthesis should be specified.

Response 3: We added the specified reasons to synthesize the title compound in the introduction.

Round 2

Reviewer 1 Report

Comments and Suggestions for Authors

The authors have improved the content of the manuscript and most of the raised issues were addressed. However, one still remains. According to the text, compound 4 (the final product) was formed in the DMSO solution as the rersult of spontaneous cyclization of the diketo intermediate. Although 1H and 13C NMR spectra are proivided properties are not.

Since compound 4 is the title product, it must be isolated and characterized by using other techniques (IR, meting point, MS, etc.) as well. Such data should be the integral part of the manuscript.

Author Response

Compound 4 was not isolated. It was only observed in NMRs.