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Review

Genetic, Environmental, and Stochastic Components of Lifespan Variability: The Drosophila Paradigm

by
Oleg V. Bylino
1,2,*,
Anna A. Ogienko
3,
Mikhail A. Batin
4,
Pavel G. Georgiev
1 and
Evgeniya S. Omelina
3,*
1
Department of Regulation of Genetic Processes, Laboratory of Molecular Organization of the Genome, Institute of Gene Biology RAS, 119334 Moscow, Russia
2
Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia
3
Department of Regulation of Genetic Processes, Institute of Molecular and Cellular Biology SB RAS, 630090 Novosibirsk, Russia
4
Open Longevity, 15260 Ventura Blvd., Sherman Oaks, Los Angeles, CA 91403, USA
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(8), 4482; https://doi.org/10.3390/ijms25084482
Submission received: 4 January 2024 / Revised: 25 March 2024 / Accepted: 5 April 2024 / Published: 19 April 2024
(This article belongs to the Special Issue Modeling Human Biological Pathways in Health, Aging and Disease: The Drosophila Paradigm - in Memory of Professor Suzanne Eaton (1959-2019))
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Abstract

Lifespan is a complex quantitative trait involving genetic and non-genetic factors as well as the peculiarities of ontogenesis. As with all quantitative traits, lifespan shows considerable variation within populations and between individuals. Drosophila, a favourite object of geneticists, has greatly advanced our understanding of how different forms of variability affect lifespan. This review considers the role of heritable genetic variability, phenotypic plasticity and stochastic variability in controlling lifespan in Drosophila melanogaster. We discuss the major historical milestones in the development of the genetic approach to study lifespan, the breeding of long-lived lines, advances in lifespan QTL mapping, the environmental factors that have the greatest influence on lifespan in laboratory maintained flies, and the mechanisms, by which individual development affects longevity. The interplay between approaches to study ageing and lifespan limitation will also be discussed. Particular attention will be paid to the interaction of different types of variability in the control of lifespan.
Keywords: Drosophila; lifespan; longevity; ageing; genetic variability; phenotypic plasticity; stochastic variability Drosophila; lifespan; longevity; ageing; genetic variability; phenotypic plasticity; stochastic variability

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MDPI and ACS Style

Bylino, O.V.; Ogienko, A.A.; Batin, M.A.; Georgiev, P.G.; Omelina, E.S. Genetic, Environmental, and Stochastic Components of Lifespan Variability: The Drosophila Paradigm. Int. J. Mol. Sci. 2024, 25, 4482. https://doi.org/10.3390/ijms25084482

AMA Style

Bylino OV, Ogienko AA, Batin MA, Georgiev PG, Omelina ES. Genetic, Environmental, and Stochastic Components of Lifespan Variability: The Drosophila Paradigm. International Journal of Molecular Sciences. 2024; 25(8):4482. https://doi.org/10.3390/ijms25084482

Chicago/Turabian Style

Bylino, Oleg V., Anna A. Ogienko, Mikhail A. Batin, Pavel G. Georgiev, and Evgeniya S. Omelina. 2024. "Genetic, Environmental, and Stochastic Components of Lifespan Variability: The Drosophila Paradigm" International Journal of Molecular Sciences 25, no. 8: 4482. https://doi.org/10.3390/ijms25084482

APA Style

Bylino, O. V., Ogienko, A. A., Batin, M. A., Georgiev, P. G., & Omelina, E. S. (2024). Genetic, Environmental, and Stochastic Components of Lifespan Variability: The Drosophila Paradigm. International Journal of Molecular Sciences, 25(8), 4482. https://doi.org/10.3390/ijms25084482

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