Unlocking the Potential of the Antimicrobial Peptide Gomesin: From Discovery and Structure–Activity Relationships to Therapeutic Applications

Liu, Xiaorong; Henriques, Sónia T.; Craik, David J.; Chan, Lai Yue

doi:10.3390/ijms24065893

Open AccessReview

Unlocking the Potential of the Antimicrobial Peptide Gomesin: From Discovery and Structure–Activity Relationships to Therapeutic Applications

by

Xiaorong Liu

^1,†

,

Sónia T. Henriques

^1,2,

David J. Craik

¹

and

Lai Yue Chan

^1,*,†

¹

Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia

²

Translational Research Institute, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD 4102, Australia

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2023, 24(6), 5893; https://doi.org/10.3390/ijms24065893

Submission received: 27 February 2023 / Revised: 17 March 2023 / Accepted: 18 March 2023 / Published: 20 March 2023

(This article belongs to the Special Issue Antimicrobial Peptides: Structure and Mechanism of Biological Activity 2.0)

Download

Browse Figures

Versions Notes

Abstract

Gomesin is a cationic antimicrobial peptide which is isolated from the haemocytes of the Brazilian tarantula Acanthoscurria gomesiana and can be produced chemically by Fmoc solid-phase peptide synthesis. Gomesin exhibits a range of biological activities, as demonstrated by its toxicity against therapeutically relevant pathogens such as Gram-positive or Gram-negative bacteria, fungi, cancer cells, and parasites. In recent years, a cyclic version of gomesin has been used for drug design and development as it is more stable than native gomesin in human serum and can penetrate and enter cancer cells. It can therefore interact with intracellular targets and has the potential to be developed as a drug lead for to treat cancer, infectious diseases, and other human diseases. This review provides a perspective on the discovery, structure–activity relationships, mechanism of action, biological activity, and potential clinical applications of gomesin.

Keywords: antimicrobial; anticancer; gomesin; β-hairpin; disulfide bonds; drug design

Share and Cite

MDPI and ACS Style

Liu, X.; Henriques, S.T.; Craik, D.J.; Chan, L.Y. Unlocking the Potential of the Antimicrobial Peptide Gomesin: From Discovery and Structure–Activity Relationships to Therapeutic Applications. Int. J. Mol. Sci. 2023, 24, 5893. https://doi.org/10.3390/ijms24065893

AMA Style

Liu X, Henriques ST, Craik DJ, Chan LY. Unlocking the Potential of the Antimicrobial Peptide Gomesin: From Discovery and Structure–Activity Relationships to Therapeutic Applications. International Journal of Molecular Sciences. 2023; 24(6):5893. https://doi.org/10.3390/ijms24065893

Chicago/Turabian Style

Liu, Xiaorong, Sónia T. Henriques, David J. Craik, and Lai Yue Chan. 2023. "Unlocking the Potential of the Antimicrobial Peptide Gomesin: From Discovery and Structure–Activity Relationships to Therapeutic Applications" International Journal of Molecular Sciences 24, no. 6: 5893. https://doi.org/10.3390/ijms24065893

APA Style

Liu, X., Henriques, S. T., Craik, D. J., & Chan, L. Y. (2023). Unlocking the Potential of the Antimicrobial Peptide Gomesin: From Discovery and Structure–Activity Relationships to Therapeutic Applications. International Journal of Molecular Sciences, 24(6), 5893. https://doi.org/10.3390/ijms24065893

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Unlocking the Potential of the Antimicrobial Peptide Gomesin: From Discovery and Structure–Activity Relationships to Therapeutic Applications

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI