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Article

Antibacterial Aloe vera Based Biocompatible Hydrogel for Use in Dermatological Applications

by
Mariana Chelu
1,
Adina Magdalena Musuc
1,*,
Ludmila Aricov
1,
Emma Adriana Ozon
2,
Andreea Iosageanu
3,
Laura M. Stefan
3,
Ana-Maria Prelipcean
3,
Monica Popa
1 and
Jose Calderon Moreno
1,*
1
“Ilie Murgulescu” Institute of Physical Chemistry, 202 Spl. Independentei, 060021 Bucharest, Romania
2
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania
3
Department of Cellular and Molecular Biology, National Institute of R&D for Biological Sciences, 296 Splaiul Independentei, 060031 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(4), 3893; https://doi.org/10.3390/ijms24043893
Submission received: 18 January 2023 / Revised: 9 February 2023 / Accepted: 13 February 2023 / Published: 15 February 2023
(This article belongs to the Special Issue Novel Natural Compound for Wound and Tissue Repair and Regeneration)
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Abstract

The present research aims to describe a new methodology to obtain biocompatible hydrogels based on Aloe vera used for wound healing applications. The properties of two hydrogels (differing in Aloe vera concentration, AV5 and AV10) prepared by an all-green synthesis method from raw, natural, renewable and bioavailable materials such as salicylic acid, allantoin and xanthan gum were investigated. The morphology of the Aloe vera based hydrogel biomaterials was studied by SEM analysis. The rheological properties of the hydrogels, as well as their cell viability, biocompatibility and cytotoxicity, were determined. The antibacterial activity of Aloe vera based hydrogels was evaluated both on Gram-positive, Staphylococcus aureus and on Gram-negative, Pseudomonas aeruginosa strains. The obtained novel green Aloe vera based hydrogels showed good antibacterial properties. In vitro scratch assay demonstrated the capacity of both AV5 and AV10 hydrogels to accelerate cell proliferation and migration and induce closure of a wounded area. A corroboration of all morphological, rheological, cytocompatibility and cell viability results indicates that this Aloe vera based hydrogel may be suitable for wound healing applications.
Keywords: Aloe vera; wound healing; hydrogels; green synthesis; allantoin; xanthan gum; antimicrobial action Aloe vera; wound healing; hydrogels; green synthesis; allantoin; xanthan gum; antimicrobial action

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MDPI and ACS Style

Chelu, M.; Musuc, A.M.; Aricov, L.; Ozon, E.A.; Iosageanu, A.; Stefan, L.M.; Prelipcean, A.-M.; Popa, M.; Moreno, J.C. Antibacterial Aloe vera Based Biocompatible Hydrogel for Use in Dermatological Applications. Int. J. Mol. Sci. 2023, 24, 3893. https://doi.org/10.3390/ijms24043893

AMA Style

Chelu M, Musuc AM, Aricov L, Ozon EA, Iosageanu A, Stefan LM, Prelipcean A-M, Popa M, Moreno JC. Antibacterial Aloe vera Based Biocompatible Hydrogel for Use in Dermatological Applications. International Journal of Molecular Sciences. 2023; 24(4):3893. https://doi.org/10.3390/ijms24043893

Chicago/Turabian Style

Chelu, Mariana, Adina Magdalena Musuc, Ludmila Aricov, Emma Adriana Ozon, Andreea Iosageanu, Laura M. Stefan, Ana-Maria Prelipcean, Monica Popa, and Jose Calderon Moreno. 2023. "Antibacterial Aloe vera Based Biocompatible Hydrogel for Use in Dermatological Applications" International Journal of Molecular Sciences 24, no. 4: 3893. https://doi.org/10.3390/ijms24043893

APA Style

Chelu, M., Musuc, A. M., Aricov, L., Ozon, E. A., Iosageanu, A., Stefan, L. M., Prelipcean, A.-M., Popa, M., & Moreno, J. C. (2023). Antibacterial Aloe vera Based Biocompatible Hydrogel for Use in Dermatological Applications. International Journal of Molecular Sciences, 24(4), 3893. https://doi.org/10.3390/ijms24043893

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