Mono- and Dimeric Sorbicillinoid Inhibitors Targeting IL-6 and IL-1β from the Mangrove-Derived Fungus Trichoderma reesei BGRg-3

Liu, Yufeng; Chen, Tao; Sun, Bing; Tan, Qi; Ouyang, Hui; Wang, Bo; Yu, Huijuan; She, Zhigang

doi:10.3390/ijms242216096

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Mono- and Dimeric Sorbicillinoid Inhibitors Targeting IL-6 and IL-1β from the Mangrove-Derived Fungus Trichoderma reesei BGRg-3

by

Yufeng Liu

^1,†,

Tao Chen

^1,†

,

Bing Sun

¹,

Qi Tan

¹,

Hui Ouyang

²,

Bo Wang

¹,

Huijuan Yu

^2,* and

Zhigang She

^1,*

¹

School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China

²

Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou 510260, China

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2023, 24(22), 16096; https://doi.org/10.3390/ijms242216096

Submission received: 23 October 2023 / Revised: 3 November 2023 / Accepted: 7 November 2023 / Published: 8 November 2023

(This article belongs to the Special Issue Natural Products and Synthetic Compounds for Drug Development)

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Abstract

Four new sorbicillinoids, named trichodermolide E (1), trichosorbicillin J (2), bisorbicillinolide B (3), and demethylsorbiquinol (5), together with eight known compounds (4, 6–12), were isolated from the cultures of the mangrove-derived fungus Trichoderma reesei BGRg-3. The structures of the new compounds were determined by analyzing their detailed spectroscopic data, while the absolute configurations were further determined through electronic circular dichroism calculations. Snatzke’s method was additionally used to determine the absolute configurations of the diol moiety in 1. In a bioassay, compounds 7 and 10 performed greater inhibitory activities on interleukin-6 and interleukin-1β than the positive control (dexamethasone) at the concentration of 25 μM. Meanwhile, compounds 5 and 6 showed potent effects with stronger inhibition than dexamethasone on IL-1β at the same concentration.

Keywords: sorbicillinoids; mangrove-derived fungus; Trichoderma reesei; anti-inflammatory activities; IL-6; IL-1β

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MDPI and ACS Style

Liu, Y.; Chen, T.; Sun, B.; Tan, Q.; Ouyang, H.; Wang, B.; Yu, H.; She, Z. Mono- and Dimeric Sorbicillinoid Inhibitors Targeting IL-6 and IL-1β from the Mangrove-Derived Fungus Trichoderma reesei BGRg-3. Int. J. Mol. Sci. 2023, 24, 16096. https://doi.org/10.3390/ijms242216096

AMA Style

Liu Y, Chen T, Sun B, Tan Q, Ouyang H, Wang B, Yu H, She Z. Mono- and Dimeric Sorbicillinoid Inhibitors Targeting IL-6 and IL-1β from the Mangrove-Derived Fungus Trichoderma reesei BGRg-3. International Journal of Molecular Sciences. 2023; 24(22):16096. https://doi.org/10.3390/ijms242216096

Chicago/Turabian Style

Liu, Yufeng, Tao Chen, Bing Sun, Qi Tan, Hui Ouyang, Bo Wang, Huijuan Yu, and Zhigang She. 2023. "Mono- and Dimeric Sorbicillinoid Inhibitors Targeting IL-6 and IL-1β from the Mangrove-Derived Fungus Trichoderma reesei BGRg-3" International Journal of Molecular Sciences 24, no. 22: 16096. https://doi.org/10.3390/ijms242216096

APA Style

Liu, Y., Chen, T., Sun, B., Tan, Q., Ouyang, H., Wang, B., Yu, H., & She, Z. (2023). Mono- and Dimeric Sorbicillinoid Inhibitors Targeting IL-6 and IL-1β from the Mangrove-Derived Fungus Trichoderma reesei BGRg-3. International Journal of Molecular Sciences, 24(22), 16096. https://doi.org/10.3390/ijms242216096

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Mono- and Dimeric Sorbicillinoid Inhibitors Targeting IL-6 and IL-1β from the Mangrove-Derived Fungus Trichoderma reesei BGRg-3

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