Review Reports - Endothelin-1 in Health and Disease

Round 1

Reviewer 1 Report

The paper entitled “Endothelin-1 in Health and Disease” is well structured and presented. The paper review different aspects of endothelin 1, physiologically and related to pathology.

This work shows that some aspects related to endothelin-1 are not completely clarified, namely the storage and release of endothelin-1. This work can pave the way to in-depth study of these topics.

The review is a little bit long, but the topics developed justify the length of the document.

Suggestion of improvement:

Line 74 - GPCR receptor - the abbreviation in full for the first time.

Author Response

Dear Reviewer,

Thank-you for your comments, the minor change (GPCR) has been made.

Best wishes

Katie and Kim

Reviewer 2 Report

1. In the legend of Figure 1, "-Simplified" be better changed to "Simplified".

2. In the legend of Figure 2, "-Simplified" be better changed to "Simplified".

3. In line 446, "exposure[36]" be better changed to "exposure [36]".

4. In the legend of Table 1 "-Summary" be better changed to "Summary".

5. In the legend of Table 2 "-Summary" be better changed to "Summary".

Author Response

Dear Reviewer,

Thank-you for your minor comments, the changes to the text as indicated have been made.

Best wishes

Katie and Kim

Reviewer 3 Report

This paper is well written! Strategies aimed at the pathways influencing the synthesis and release of ET-1 pathway remain limited.

In circulation research, the forms of vascular arteries play an important role in endothelin -1 in Health and Disease. Blood flow in arteies should be take into consideration will become much better.

Author Response

Dear Reviewer,

Thank-you for your time in reviewing our paper and your positive comments. We have not made changes to the text.

Best wishes

Katie and Kim