Next Article in Journal
Prospects of Testing Diurnal Profiles of Expressions of TSH-R and Circadian Clock Genes in Thyrocytes for Identification of Preoperative Biomarkers for Thyroid Carcinoma
Next Article in Special Issue
Identification of Prognostic Gene Signatures by Developing a scRNA-Seq-Based Integration Approach to Predict Recurrence and Chemotherapy Benefit in Stage II–III Colorectal Cancer
Previous Article in Journal
Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of Synaptic Kinase-Mediated Signaling
Previous Article in Special Issue
Collagen Type XI Inhibits Lung Cancer-Associated Fibroblast Functions and Restrains the Integrin Binding Site Availability on Collagen Type I Matrix
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 23
Issue 20
10.3390/ijms232012210
Review Report
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Wnt Signaling and Aging of the Gastrointestinal Tract

Int. J. Mol. Sci. 2022, 23(20), 12210; https://doi.org/10.3390/ijms232012210
by Naoki Asano *, Akio Takeuchi, Akira Imatani, Masashi Saito, Xiaoyi Jin, Waku Hatta, Kaname Uno, Tomoyuki Koike and Atsushi Masamune
Reviewer 1:
Irina Pronina
Reviewer 2:
Dan Chen
Int. J. Mol. Sci. 2022, 23(20), 12210; https://doi.org/10.3390/ijms232012210
Submission received: 20 September 2022 / Revised: 10 October 2022 / Accepted: 10 October 2022 / Published: 13 October 2022
(This article belongs to the Collection Feature Papers in Molecular Oncology)

Round 1

Reviewer 1 Report

In the submitted manuscript "Wnt Signaling and Aging of the Gastrointestinal Tract", the authors briefly but in sufficient detail described the Wnt signaling pathway and its involvement in the aging process of individual cells, including cells of the gastrointestinal tract. Separately, the authors focused on the role of the Wnt signaling pathway in carcinogenesis and possible dysregulation of the Wnt signaling pathway leading to the transition of a stem cell from normal aging to tumorigenesis.

The manuscript needs some minor editing in English. For example, line 162 and line 184, instead of Present Continuous "is playing" it is better to use Present Simple "plays".

Author Response

The authors would like to thank the reviewer for reviewing our manuscript and for his/her comments.

We have carefully checked our manuscript and made corrections where needed.

We really appreciate the reviewer for taking his/her time and helping us improve our manuscript.

Author Response File: Author Response.docx

Reviewer 2 Report

Asano et al highlighted the effect of Wnt signaling in the aging of gastrointestinal tract and aging-related carcinogenesis. Overall, the review is well performed, but there are little minor points the author would need to address.

 

Minor points:

1.     As Wnt signaling plays a controversial role in regulating aging. Discuss some potential therapy targets (inhibitor or agonist) or hypothesis for the future research on Wnt signaling regulating the aging of gastrointestinal tract and aging-related carcinogenesis.

Author Response

We thank the reviewer for reviewing our manuscript and for his/her comments.

As proposed by the reviewer, we have added a new section "Future Perspectives" which discusses about potential Wnt signaling-related therapy for aging-related gastric cancers.

We really appreciate the reviewer for taking his/her time and helping us improve our manuscript.

Author Response File: Author Response.docx

Back to TopTop