Progress of Nanomaterials-Based Photothermal Therapy for Oral Squamous Cell Carcinoma
, Yunfan Zhang 1,2, Zimeng Zhuang 1,2, Xin Zhang 1,2, Tianyi Xin 1,2, Si Chen 1,2,* and Bing Han 1,2,*Round 1
Reviewer 1 Report
This review focuses on the field of OSCC and the use of nanomaterial-mediated PTT. While it divided nanomaterials into 4 categories: noble metal nanomaterials, carbon-based nanomaterials, metal compounds, and organic nanoparticles.
attached are my specific comments.
Comments for author File: 
Comments.pdf
Author Response
Response to Reviewer 1 Comments
We would like to express our appreciation to both reviewers for their constructive remarks and useful suggestions, which have significantly raised the quality of the manuscript. According to the referees’ suggestions, we have conducted detailed revision. The revised parts in the manuscript are shadowed in yellow. Thank you very much for your consideration in advance.
Reviewers' comments:
Reviewer #1: This review focuses on the field of OSCC and the use of nanomaterial-mediated PTT. While it divided nanomaterials into 4 categories: noble metal nanomaterials, carbon-based nanomaterials, metal compounds, and organic nanoparticles. Attached are my specific comments.
Response: Thanks for these positive comments. According to these suggestions, we added references and corrected formatting errors in the manuscript. We also supplemented the examples of surface modification of noble metal nanomaterials, the types of tumors treated by noble metal nanomaterials, and the effects of gold nanomaterials on cancer cells. The revised parts in the revised manuscript are shadowed in yellow.
Reviewer 2 Report
To Authors
- Title
The title communicates distinctly what the manuscript is about, but it should be better indicated as a review; no unnecessary description is reported.
- Abstract
The abstract provides an explicit statement of the review's main objectives and topics.
- Introduction
The introduction describes the rationale for the review in the context of what is already known. The introduction has a good presentation relating to PTT and PTAs, making the text usable /understandable even for those who do not know the subject directly and making the rest of the text more understandable.
Figure 1 should be improved for a better understanding of category titles. It should be better specified for each category which are the materials dealt with in the text. Unfortunately, the drawings alone, however decorative, are superfluous.
- Main text on nanomaterials
Carefully check abbreviations, and where possible reduce their use to increase the intelligibility and simplicity of the text. The title of Table 3 needs to be changed (it has the same text as Table 1). In the text, the position of figure 6 needs to be adjusted.
- Conclusions and outlooks
In this final discussion section, the future findings for this review should be presented for the main topics. The challenges of the clinical application of PTT nanomaterials and future improvement should be enhanced. The implications of the findings for future research and potential applications should be better considered.
Author Response
Response to Reviewer 2 Comments
We would like to express our appreciation to both reviewers for their constructive remarks and useful suggestions, which have significantly raised the quality of the manuscript. According to the referees’ suggestions, we have conducted detailed revision. The revised parts in the manuscript are shadowed in yellow. Thank you very much for your consideration in advance.
Reviewers' comments:
Reviewer #2:
Point 1: The title communicates distinctly what the manuscript is about, but it should be better indicated as a review; no unnecessary description is reported.
Response 1: Thanks for this comment, we have changed the title to “Progress of Nanomaterials-based Photothermal Therapy for Oral Squamous Cell Carcinoma”.
Point 2: Figure 1 should be improved for a better understanding of category titles. It should be better specified for each category which are the materials dealt with in the text. Unfortunately, the drawings alone, however decorative, are superfluous.
Response 2: Thanks for this comment, we have improved Figure 1. Currently Figure 1 contains more detailed classifications and each picture matched the specific classification.
Point 3: Carefully check abbreviations, and where possible reduce their use to increase the intelligibility and simplicity of the text. The title of Table 3 needs to be changed (it has the same text as Table 1). In the text, the position of figure 6 needs to be adjusted.
Response 3: Thanks for this comment, we are sorry for our negligence. We reduced the use of abbreviations such as MMP, PDX, DOC, CDT, CDX, OTSCC, uPAR, CXCR, RPTT, ·OH, NSC, ML, DCs and CCM. We also changed the title of Table 3 to “A summary of organic nanomaterials for PTT in OSCC” and adjusted the position of Figure 6 in the revised manuscript.
Point 4: In this final discussion section, the future findings for this review should be presented for the main topics. The challenges of the clinical application of PTT nanomaterials and future improvement should be enhanced. The implications of the findings for future research and potential applications should be better considered.
Response 4: Thanks for this helpful suggestion. We have enriched relevant content to highlight the challenges faced by existing nanomaterials. We noted that the clinical transformation of PTT is still an insurmountable challenge faced by PTT. The long-term safety of nanoparticles and limited shallow penetration depth of near-infrared light. Subsequently, we further proposed the directions to solve these problems, including the development of novel photothermal nanomaterials, the application of drug delivery systems and synergistic therapy. We hoped that our review could provide directions and ideas for future improvement of photothermal nanomaterials. The increased parts in the revised manuscript are shadowed in yellow.
