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Volume 22
Issue 7
10.3390/ijms22073778
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Article
Peer-Review Record

Study on Demethoxycurcumin as a Promising Approach to Reverse Methicillin-Resistance of Staphylococcus aureus

Int. J. Mol. Sci. 2021, 22(7), 3778; https://doi.org/10.3390/ijms22073778
by Qian-Qian Li, Ok-Hwa Kang * and Dong-Yeul Kwon *
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2021, 22(7), 3778; https://doi.org/10.3390/ijms22073778
Submission received: 8 March 2021 / Revised: 31 March 2021 / Accepted: 3 April 2021 / Published: 6 April 2021
(This article belongs to the Special Issue Antimicrobial Resistance-New Insights)

Round 1

Reviewer 1 Report

The manuscript as entitled as Study on Demethoxycurcumin as a promising approach to reverse methicillin-resistance of Staphylococcus aureus is well written. The article explains the comprehensive study of DMC's effect on MRSA. My only reservation is the lack of novelty and potent activity of DMC. Some of the typos and uniformity issues need to be addressed before publication. 

Comments for author File: Comments.pdf

Author Response

Please see the attached file

Author Response File: Author Response.docx

Reviewer 2 Report

General: please make sure to define every abbreviation before use

Please make sure to use italics when discussing bacterial names

Abstract:

„thorny” please use a different word

phytochemical components

…for eliminating MRSA.

L27: that may cause

L29: Please consider including a following reference and discuss in more detail the clinical relevance of S. aureus/MRSA:

https://pubmed.ncbi.nlm.nih.gov/31052511/

L40: classical risk factors

L48: Because the cell wall…Gram-positive

L55: please also discuss that the most commonly used antibiotics taken for non-prescription use/self-medication use are beta-lactam agents and this also facilitates the emergence of methicillin-resistance, see reference:

https://pubmed.ncbi.nlm.nih.gov/32932630/

L61-65: please also note that another genetic determinant (mecC) is also possible to induce methicillin-resistance

L77: Zingiberaceae in italics

L106: and the curcuminoid

of the MIC values

L121: either re-designate the main section as „results and discussion” or remove the reference as it is not customary to have references in the Results

Please provide a color Figure on the preparation of the FICI assay.

wouldn’t it be more appropriate to calculuate some kind of other value (e.g., combination index (CI), see literature!

L174-176: do not forget PBP2c!!

L226-228: Please consider including the following reference:

https://www.nature.com/articles/s41598-020-74834-y

The discussion in its current form contains a lot of information that is already well-known. Instead, please try to better contextualize the significance of your findings in line with other recent experimental results. Try to restructure the discussion section accordingly.

Author Response

Please see the attached file

Author Response File: Author Response.docx

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