Next Article in Journal
Mechanical Brain Injury Increases Cells’ Production of Cystathionine β-Synthase and Glutamine Synthetase, but Reduces Pax2 Expression in the Telencephalon of Juvenile Chum Salmon, Oncorhynchus keta
Next Article in Special Issue
Distinct Effects of Escherichia coli,Pseudomonas aeruginosa and Staphylococcus aureus Cell Wall Component-Induced Inflammation on the Iron Metabolism of THP-1 Cells
Previous Article in Journal
Effects of CREG1 on Age-Associated Metabolic Phenotypes and Renal Senescence in Mice
Previous Article in Special Issue
HIF1A: A Putative Modifier of Hemochromatosis
 
 
Review
Peer-Review Record

The Role of GSH in Intracellular Iron Trafficking

Int. J. Mol. Sci. 2021, 22(3), 1278; https://doi.org/10.3390/ijms22031278
by Robert Hider *, Mayra Vera Aviles, Yu-Lin Chen and Gladys Oluyemisi Latunde-Dada
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2021, 22(3), 1278; https://doi.org/10.3390/ijms22031278
Submission received: 30 December 2020 / Revised: 14 January 2021 / Accepted: 18 January 2021 / Published: 28 January 2021

Round 1

Reviewer 1 Report

The authors well described intracellular iron ion complexes and GSH function in different cell organelles. 

I would like to suggest provide detailed information of some abbreviation, such as DMT1, IRP. 

 

 

Author Response

Reviewer 1 was complimentary to our submission but suggested that we provide a list of abbreviations. We have introduced such a list before the reference section.

Reviewer 2 Report

This is a very interesting review considering the role of glutathione as a ligand for cytosolic iron. I would recommend adding a section where the importance of glutathione as an iron ligand with respect to specific diseases, such as neurodegenerative diseases, would be discussed. This would support the importance of the issue discussed for the readers. 

 

Author Response

Reviewer 2 finds that our manuscript is interesting, but suggested that we should add a section discussing the relationship of glutathione with neurodegeneration. This is a good suggestion and we have introduced a new paragraph discussing this matter. This is the penultimate paragraph in section 5. We have introduced four additional references in this paragraph.

Back to TopTop