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Article

Activation of Transposable Elements in Immune Cells of Fibromyalgia Patients

1
School of Medicine, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain
2
Université de Poitiers, CEDEX, 86073 Poitiers, France
3
Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, 46008 Valencia, Spain
4
School of Biotechnology, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain
5
National Health Service, Manises Hospital, 46940 Valencia, Spain
6
Institute for Neuro Immune Medicine, Nova Southeastern University, Ft Lauderdale, FL 33314, USA
7
Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(4), 1366; https://doi.org/10.3390/ijms21041366
Received: 26 December 2019 / Revised: 6 February 2020 / Accepted: 14 February 2020 / Published: 18 February 2020
Advancements in nucleic acid sequencing technology combined with an unprecedented availability of metadata have revealed that 45% of the human genome constituted by transposable elements (TEs) is not only transcriptionally active but also physiologically necessary. Dysregulation of TEs, including human retroviral endogenous sequences (HERVs) has been shown to associate with several neurologic and autoimmune diseases, including Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). However, no study has yet addressed whether abnormal expression of these sequences correlates with fibromyalgia (FM), a disease frequently comorbid with ME/CFS. The work presented here shows, for the first time, that, in fact, HERVs of the H, K and W types are overexpressed in immune cells of FM patients with or without comorbid ME/CFS. Patients with increased HERV expression (N = 14) presented increased levels of interferon (INF-β and INF-γ) but unchanged levels of TNF-α. The findings reported in this study could explain the flu-like symptoms FM patients present with in clinical practice, in the absence of concomitant infections. Future work aimed at identifying specific genomic loci differentially affected in FM and/or ME/CFS is warranted. View Full-Text
Keywords: fibromyalgia; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); human endogenous retrovirus (HERV); transposable elements; epigenetics; DNA methylation; transfer RNA small fragments (tsRNAs); interferon (INF); non-Hodgkin’s lymphoma fibromyalgia; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); human endogenous retrovirus (HERV); transposable elements; epigenetics; DNA methylation; transfer RNA small fragments (tsRNAs); interferon (INF); non-Hodgkin’s lymphoma
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MDPI and ACS Style

Ovejero, T.; Sadones, O.; Sánchez-Fito, T.; Almenar-Pérez, E.; Espejo, J.A.; Martín-Martínez, E.; Nathanson, L.; Oltra, E. Activation of Transposable Elements in Immune Cells of Fibromyalgia Patients. Int. J. Mol. Sci. 2020, 21, 1366. https://doi.org/10.3390/ijms21041366

AMA Style

Ovejero T, Sadones O, Sánchez-Fito T, Almenar-Pérez E, Espejo JA, Martín-Martínez E, Nathanson L, Oltra E. Activation of Transposable Elements in Immune Cells of Fibromyalgia Patients. International Journal of Molecular Sciences. 2020; 21(4):1366. https://doi.org/10.3390/ijms21041366

Chicago/Turabian Style

Ovejero, Tamara, Océane Sadones, Teresa Sánchez-Fito, Eloy Almenar-Pérez, José Andrés Espejo, Eva Martín-Martínez, Lubov Nathanson, and Elisa Oltra. 2020. "Activation of Transposable Elements in Immune Cells of Fibromyalgia Patients" International Journal of Molecular Sciences 21, no. 4: 1366. https://doi.org/10.3390/ijms21041366

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