Review Reports - Mutual Regulation of RNA Silencing and the IFN Response as an Antiviral Defense System in Mammalian Cells

Round 1

Reviewer 1 Report

The authors present a well written, informative review about what is known about the cross-talk between IFN response and RNA silencing. The manuscript is informative and provides a state-of-the-art review.

The paragraph beginning line 43 needs extensive references. The authors state a wide range of work has been performed, but do not provide the references to that work.

Author Response

Dear Reviewer,

Thank you for your valuable comment.

We provided the references [6-25] and [26-33] to the paragraph beginning line 43.

We believe that these corrections have improved our manuscript. I hope our revised manuscript will be satisfactory to you.

Yours sincerely,

Kumiko Ui-Tei

Department of Biological Sciences, Graduate School of Science, The University of Tokyo

Email: ktei@bs.s.u-tokyo.ac.jp

Reviewer 2 Report

This is a very interesting review that describes the interactions of RNA binding proteins that are involved in the RNA silencing as well as in the Interferon Response in mammalian cells. The authors discuss a potential functional overlap of both pathways in the cell that were yet considered to be strictly Independent. These are important considerations that should be published.