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Open AccessArticle

Serenoa repens and Urtica dioica Fixed Combination: In-Vitro Validation of a Therapy for Benign Prostatic Hyperplasia (BPH)

1
Department of Medicine, University of Padova, 35128 Padova, Italy
2
Veneto Institute of Molecular Medicine, 35129 Padova, Italy
3
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padua, Italy
4
Clinical Research Department of Schwabe Pharma Italia, 39100 Bolzano, Italy
5
Department of Medical Oncology-Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy
6
Urological Clinic, Department of Surgical, Oncological and Gastroenterological Sciences, School of Medicine and Surgery, University of Padova, 35124 Padova, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(23), 9178; https://doi.org/10.3390/ijms21239178
Received: 2 November 2020 / Revised: 26 November 2020 / Accepted: 30 November 2020 / Published: 2 December 2020
(This article belongs to the Special Issue Nutraceuticals in Chronic Diseases)
Benign prostatic hyperplasia (BPH) is an age-related chronic disorder, characterized by the hyperproliferation of prostatic epithelial and stromal cells, which drives prostate enlargement. Since BPH aetiology and progression have been associated with the persistence of an inflammatory stimulus, induced both by Nuclear Factor-kappa B (NF-κB) activation and reactive oxygen species (ROS) production, the inhibition of these pathways could result in a good tool for its clinical treatment. This study aimed to evaluate the antioxidant and anti-inflammatory activity of a combined formulation of Serenoa repens and Urtica dioica (SR/UD) in an in vitro human model of BPH. The results confirmed both the antioxidant and the anti-inflammatory effects of SR/UD. In fact, SR/UD simultaneously reduced ROS production, NF-κB translocation inside the nucleus, and, consequently, interleukin 6 (IL-6) and interleukin 8 (IL-8) production. Furthermore, the effect of SR/UD was also tested in a human androgen-independent prostate cell model, PC3. SR/UD did not show any significant antioxidant and anti-inflammatory effect, but was able to reduce NF-κB translocation. Taken together, these results suggested a promising role of SR/UD in BPH and BPH-linked disorder prevention. View Full-Text
Keywords: BPH; inflammation; oxidative stress; Serenoa repens; Urtica dioica BPH; inflammation; oxidative stress; Serenoa repens; Urtica dioica
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MDPI and ACS Style

Saponaro, M.; Giacomini, I.; Morandin, G.; Cocetta, V.; Ragazzi, E.; Orso, G.; Carnevali, I.; Berretta, M.; Mancini, M.; Pagano, F.; Montopoli, M. Serenoa repens and Urtica dioica Fixed Combination: In-Vitro Validation of a Therapy for Benign Prostatic Hyperplasia (BPH). Int. J. Mol. Sci. 2020, 21, 9178. https://doi.org/10.3390/ijms21239178

AMA Style

Saponaro M, Giacomini I, Morandin G, Cocetta V, Ragazzi E, Orso G, Carnevali I, Berretta M, Mancini M, Pagano F, Montopoli M. Serenoa repens and Urtica dioica Fixed Combination: In-Vitro Validation of a Therapy for Benign Prostatic Hyperplasia (BPH). International Journal of Molecular Sciences. 2020; 21(23):9178. https://doi.org/10.3390/ijms21239178

Chicago/Turabian Style

Saponaro, Miriam; Giacomini, Isabella; Morandin, Giulia; Cocetta, Veronica; Ragazzi, Eugenio; Orso, Genny; Carnevali, Ilaria; Berretta, Massimiliano; Mancini, Mariangela; Pagano, Francesco; Montopoli, Monica. 2020. "Serenoa repens and Urtica dioica Fixed Combination: In-Vitro Validation of a Therapy for Benign Prostatic Hyperplasia (BPH)" Int. J. Mol. Sci. 21, no. 23: 9178. https://doi.org/10.3390/ijms21239178

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