Next Article in Journal
The Role of Nitric Oxide in Cancer: Master Regulator or NOt?
Next Article in Special Issue
Strain-Specific Effects of Bifidobacterium longum on Hypercholesterolemic Rats and Potential Mechanisms
Previous Article in Journal
Liposomes Targeting P21 Activated Kinase-1 (PAK-1) and Selective for Secretory Phospholipase A2 (sPLA2) Decrease Cell Viability and Induce Apoptosis in Metastatic Triple-Negative Breast Cancer Cells
Previous Article in Special Issue
Serenoa repens and Urtica dioica Fixed Combination: In-Vitro Validation of a Therapy for Benign Prostatic Hyperplasia (BPH)
Open AccessReview

Brassica Bioactives Could Ameliorate the Chronic Inflammatory Condition of Endometriosis

1
Aquaporins Group, Centro de Edafologia y Biologia Aplicada del Segura, CEBAS-CSIC, Campus Universitario de Espinardo-25, E-30100 Murcia, Spain
2
Department of Biochemistry, Molecular Biology B and Immunology, School of Medicine, University of Murcia Regional Campus of International Excellence “Campus Mare Nostrum”, 30100 Murcia, Spain
3
Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain
4
Phytochemistry and Healthy Foods Lab, Department of Food Science Technology, Centro de Edafologia y Biologia Aplicada del Segura, CEBAS-CSIC, Campus de Espinardo-25, E-30100 Murcia, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(24), 9397; https://doi.org/10.3390/ijms21249397
Received: 7 November 2020 / Revised: 26 November 2020 / Accepted: 5 December 2020 / Published: 10 December 2020
(This article belongs to the Special Issue Nutraceuticals in Chronic Diseases)
Endometriosis is a chronic, inflammatory, hormone-dependent disease characterized by histological lesions produced by the presence of endometrial tissue outside the uterine cavity. Despite the fact that an estimated 176 million women are affected worldwide by this gynecological disorder, risk factors that cause endometriosis have not been properly defined and current treatments are not efficient. Although the interaction between diet and human health has been the focus of many studies, little information about the correlation of foods and their bioactive derivates with endometriosis is available. In this framework, Brassica crops have emerged as potential candidates for ameliorating the chronic inflammatory condition of endometriosis, due to their abundant content of health-promoting compounds such as glucosinolates and their hydrolysis products, isothiocyanates. Several inflammation-related signaling pathways have been included among the known targets of isothiocyanates, but those involving aquaporin water channels have an important role in endometriosis. Therefore, the aim of this review is to highlight the promising effects of the phytochemicals present in Brassica spp. as major candidates for inclusion in a dietary approach aiming to improve the inflammatory condition of women affected with endometriosis. This review points out the potential roles of glucosinolates and isothiocyanates from Brassicas as anti-inflammatory compounds, which might contribute to a reduction in endometriosis symptoms. In view of these promising results, further investigation of the effect of glucosinolates on chronic inflammatory diseases, either as diet coadjuvants or as therapeutic molecules, should be performed. In addition, we highlight the involvement of aquaporins in the maintenance of immune homeostasis. In brief, glucosinolates and the modulation of cellular water by aquaporins could shed light on new approaches to improve the quality of life for women with endometriosis. View Full-Text
Keywords: aquaporins; Brassica; isothiocyanates; indoles; endometriosis; inflammation aquaporins; Brassica; isothiocyanates; indoles; endometriosis; inflammation
Show Figures

Figure 1

MDPI and ACS Style

García-Ibañez, P.; Yepes-Molina, L.; Ruiz-Alcaraz, A.J.; Martínez-Esparza, M.; Moreno, D.A.; Carvajal, M.; García-Peñarrubia, P. Brassica Bioactives Could Ameliorate the Chronic Inflammatory Condition of Endometriosis. Int. J. Mol. Sci. 2020, 21, 9397. https://doi.org/10.3390/ijms21249397

AMA Style

García-Ibañez P, Yepes-Molina L, Ruiz-Alcaraz AJ, Martínez-Esparza M, Moreno DA, Carvajal M, García-Peñarrubia P. Brassica Bioactives Could Ameliorate the Chronic Inflammatory Condition of Endometriosis. International Journal of Molecular Sciences. 2020; 21(24):9397. https://doi.org/10.3390/ijms21249397

Chicago/Turabian Style

García-Ibañez, Paula; Yepes-Molina, Lucía; Ruiz-Alcaraz, Antonio J.; Martínez-Esparza, María; Moreno, Diego A.; Carvajal, Micaela; García-Peñarrubia, Pilar. 2020. "Brassica Bioactives Could Ameliorate the Chronic Inflammatory Condition of Endometriosis" Int. J. Mol. Sci. 21, no. 24: 9397. https://doi.org/10.3390/ijms21249397

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop