Next Article in Journal
Exposure to Endocrine Disrupting Chemicals and Risk of Breast Cancer
Next Article in Special Issue
Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice
Previous Article in Journal
The Effect of Methylmalonic Acid Treatment on Human Neuronal Cell Coenzyme Q10 Status and Mitochondrial Function
Open AccessReview

TGF-β Pathway in Salivary Gland Fibrosis

by 1,2,†, 2,3,4,†, 2,3, 2,3,4, 2,3,* and 2,3,4,*
1
Department of Pathology, Yanbian University Hospital, Yanji, Jilin 133000, China
2
Oral Cancer Research Institute, Yonsei University College of Dentistry, Seoul 03722, Korea
3
Department of Oral Pathology, Yonsei University College of Dentistry, Seoul 03722, Korea
4
BK21 FOUR Project, Yonsei University College of Dentistry, Seoul 03722, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(23), 9138; https://doi.org/10.3390/ijms21239138
Received: 23 October 2020 / Revised: 26 November 2020 / Accepted: 27 November 2020 / Published: 30 November 2020
(This article belongs to the Special Issue Recent Advances in Salivary Gland and Their Function)
Fibrosis is presented in various physiologic and pathologic conditions of the salivary gland. Transforming growth factor beta (TGF-β) pathway has a pivotal role in the pathogenesis of fibrosis in several organs, including the salivary glands. Among the TGF-β superfamily members, TGF-β1 and 2 are pro-fibrotic ligands, whereas TGF-β3 and some bone morphogenetic proteins (BMPs) are anti-fibrotic ligands. TGF-β1 is thought to be associated with the pro-fibrotic pathogenesis of sialadenitis, post-radiation salivary gland dysfunction, and Sjögren’s syndrome. Potential therapeutic strategies that target multiple levels in the TGF-β pathway are under preclinical and clinical research for fibrosis. Despite the anti-fibrotic effect of BMPs, their in vivo delivery poses a challenge in terms of adequate clinical efficacy. In this article, we will review the relevance of TGF-β signaling in salivary gland fibrosis and advances of potential therapeutic options in the field. View Full-Text
Keywords: TGF-β; BMP; salivary gland; fibrosis; sialadenitis; Sjögren’s syndrome; drug delivery TGF-β; BMP; salivary gland; fibrosis; sialadenitis; Sjögren’s syndrome; drug delivery
Show Figures

Figure 1

MDPI and ACS Style

Zhang, X.; Yun, J.S.; Han, D.; Yook, J.I.; Kim, H.S.; Cho, E.S. TGF-β Pathway in Salivary Gland Fibrosis. Int. J. Mol. Sci. 2020, 21, 9138.

AMA Style

Zhang X, Yun JS, Han D, Yook JI, Kim HS, Cho ES. TGF-β Pathway in Salivary Gland Fibrosis. International Journal of Molecular Sciences. 2020; 21(23):9138.

Chicago/Turabian Style

Zhang, Xianglan; Yun, Jun S.; Han, Dawool; Yook, Jong I.; Kim, Hyun S.; Cho, Eunae S. 2020. "TGF-β Pathway in Salivary Gland Fibrosis" Int. J. Mol. Sci. 21, no. 23: 9138.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop