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Open AccessReview

Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases

1
The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia
2
Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia
3
University Paris-Saclay, INSERM UMR 1270, Gustave Roussy, 94800 Villejuif, France
4
University of Bordeaux, INSERM U1034, Biology of Cardiovascular Diseases, 33600 Pessac, France
5
Laboratory of Hematology, Bordeaux University Hospital Center, Haut-Leveque Hospital, 33604 Pessac, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(20), 7591; https://doi.org/10.3390/ijms21207591
Received: 11 September 2020 / Revised: 9 October 2020 / Accepted: 10 October 2020 / Published: 14 October 2020
(This article belongs to the Special Issue Advances in Bcl-xL Research 2020)
Blood platelets have important roles in haemostasis, where they quickly stop bleeding in response to vascular damage. They have also recognised functions in thrombosis, immunity, antimicrobal defense, cancer growth and metastasis, tumour angiogenesis, lymphangiogenesis, inflammatory diseases, wound healing, liver regeneration and neurodegeneration. Their brief life span in circulation is strictly controlled by intrinsic apoptosis, where the prosurvival Bcl-2 family protein, Bcl-xL, has a major role. Blood platelets are produced by large polyploid precursor cells, megakaryocytes, residing mainly in the bone marrow. Together with Mcl-1, Bcl-xL regulates megakaryocyte survival. This review describes megakaryocyte maturation and survival, platelet production, platelet life span and diseases of abnormal platelet number with a focus on the role of Bcl-xL during these processes. View Full-Text
Keywords: platelet; megakaryocyte; Bcl-xL platelet; megakaryocyte; Bcl-xL
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MDPI and ACS Style

Josefsson, E.C.; Vainchenker, W.; James, C. Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases. Int. J. Mol. Sci. 2020, 21, 7591. https://doi.org/10.3390/ijms21207591

AMA Style

Josefsson EC, Vainchenker W, James C. Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases. International Journal of Molecular Sciences. 2020; 21(20):7591. https://doi.org/10.3390/ijms21207591

Chicago/Turabian Style

Josefsson, Emma C.; Vainchenker, William; James, Chloe. 2020. "Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases" Int. J. Mol. Sci. 21, no. 20: 7591. https://doi.org/10.3390/ijms21207591

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