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Review

The Role of Bcl-xL Protein in Viral Infections

1
Institute of Biological Sciences, Cardinal Stefan Wyszyński University in Warsaw, 01-815 Warsaw, Poland
2
Department of Biochemistry and Microbiology, Institute of Biology, Warsaw University of Life Sciences-SGGW, 02-787 Warsaw, Poland
3
Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-787 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Mario Milani
Int. J. Mol. Sci. 2021, 22(4), 1956; https://doi.org/10.3390/ijms22041956
Received: 28 January 2021 / Revised: 13 February 2021 / Accepted: 14 February 2021 / Published: 16 February 2021
(This article belongs to the Special Issue Advances in Bcl-xL Research 2.0)
Bcl-xL represents a family of proteins responsible for the regulation of the intrinsic apoptosis pathway. Due to its anti-apoptotic activity, Bcl-xL co-determines the viability of various virally infected cells. Their survival may determine the effectiveness of viral replication and spread, dynamics of systemic infection, and viral pathogenesis. In this paper, we have reviewed the role of Bcl-xL in the context of host infection by eight different RNA and DNA viruses: hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), influenza A virus (IAV), Epstein-Barr virus (EBV), human T-lymphotropic virus type-1 (HTLV-1), Maraba virus (MRBV), Schmallenberg virus (SBV) and coronavirus (CoV). We have described an influence of viral infection on the intracellular level of Bcl-xL and discussed the impact of Bcl-xL-dependent cell survival control on infection-accompanying pathogenic events such as tissue damage or oncogenesis. We have also presented anti-viral treatment strategies based on the pharmacological regulation of Bcl-xL expression or activity. View Full-Text
Keywords: Bcl-xL; HBV; HCV; HIV; IAV; EBV; HTLV-1; MRBV; SBV; CoV Bcl-xL; HBV; HCV; HIV; IAV; EBV; HTLV-1; MRBV; SBV; CoV
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MDPI and ACS Style

Wyżewski, Z.; Świtlik, W.; Mielcarska, M.B.; Gregorczyk-Zboroch, K.P. The Role of Bcl-xL Protein in Viral Infections. Int. J. Mol. Sci. 2021, 22, 1956. https://doi.org/10.3390/ijms22041956

AMA Style

Wyżewski Z, Świtlik W, Mielcarska MB, Gregorczyk-Zboroch KP. The Role of Bcl-xL Protein in Viral Infections. International Journal of Molecular Sciences. 2021; 22(4):1956. https://doi.org/10.3390/ijms22041956

Chicago/Turabian Style

Wyżewski, Zbigniew, Weronika Świtlik, Matylda B. Mielcarska, and Karolina P. Gregorczyk-Zboroch 2021. "The Role of Bcl-xL Protein in Viral Infections" International Journal of Molecular Sciences 22, no. 4: 1956. https://doi.org/10.3390/ijms22041956

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