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Review

Adipose Tissue Fibrosis: Mechanisms, Models, and Importance

1
Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
2
Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(17), 6030; https://doi.org/10.3390/ijms21176030
Received: 27 July 2020 / Revised: 15 August 2020 / Accepted: 17 August 2020 / Published: 21 August 2020
(This article belongs to the Special Issue Cells and Materials for Disease Modeling and Regenerative Medicine)
Increases in adipocyte volume and tissue mass due to obesity can result in inflammation, further dysregulation in adipose tissue function, and eventually adipose tissue fibrosis. Like other fibrotic diseases, adipose tissue fibrosis is the accumulation and increased production of extracellular matrix (ECM) proteins. Adipose tissue fibrosis has been linked to decreased insulin sensitivity, poor bariatric surgery outcomes, and difficulty in weight loss. With the rising rates of obesity, it is important to create accurate models for adipose tissue fibrosis to gain mechanistic insights and develop targeted treatments. This article discusses recent research in modeling adipose tissue fibrosis using in vivo and in vitro (2D and 3D) methods with considerations for biomaterial selections. Additionally, this article outlines the importance of adipose tissue in treating other fibrotic diseases and methods used to detect and characterize adipose tissue fibrosis. View Full-Text
Keywords: adipose tissue; fibrosis; in vitro models; in vivo models; biomaterials adipose tissue; fibrosis; in vitro models; in vivo models; biomaterials
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MDPI and ACS Style

DeBari, M.K.; Abbott, R.D. Adipose Tissue Fibrosis: Mechanisms, Models, and Importance. Int. J. Mol. Sci. 2020, 21, 6030. https://doi.org/10.3390/ijms21176030

AMA Style

DeBari MK, Abbott RD. Adipose Tissue Fibrosis: Mechanisms, Models, and Importance. International Journal of Molecular Sciences. 2020; 21(17):6030. https://doi.org/10.3390/ijms21176030

Chicago/Turabian Style

DeBari, Megan K., and Rosalyn D. Abbott. 2020. "Adipose Tissue Fibrosis: Mechanisms, Models, and Importance" International Journal of Molecular Sciences 21, no. 17: 6030. https://doi.org/10.3390/ijms21176030

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