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Open AccessReview

Interleukin-6 in Rheumatoid Arthritis

1
Allergy and Clinical Immunology, Fondazione Policlinico Universitario A, Gemelli IRCCS, Catholic University, 00168 Rome, Italy
2
Emergency Medicine, Fondazione Policlinico Universitario A, Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(15), 5238; https://doi.org/10.3390/ijms21155238
Received: 2 July 2020 / Revised: 18 July 2020 / Accepted: 20 July 2020 / Published: 23 July 2020
The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development and progression of rheumatoid arthritis (RA), opening interesting perspectives in terms of therapy. Anti-IL-6 drugs are being used with variable degrees of success in other diseases and are being tested in RA. Results have been encouraging, particularly when anti-IL-6 has been used with other drugs, such as metothrexate (MTX). In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA, but despite the main therapeutic options available to target IL-6, no gold standard treatment has been established so far. View Full-Text
Keywords: IL-6; rheumatoid arthritis; inflammation IL-6; rheumatoid arthritis; inflammation
MDPI and ACS Style

Franco, P.; Laura, F.; Valentina, C.; Simona, A.; Gloria, A.; Eleonora, N. Interleukin-6 in Rheumatoid Arthritis. Int. J. Mol. Sci. 2020, 21, 5238.

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