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Article

Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice

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Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 59 Nanyang Drive, Singapore 636921, Singapore
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Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, 61 Biopolis Dr., Singapore 138673, Singapore
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Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, Singapore 169856, Singapore
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Academic Clinical Program in Ophthalmology, DUKE-NUS Graduate School of Medicine, Singapore 169857, Singapore
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Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 7, Singapore 119228, Singapore
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School of Biological Sciences, Nanyang Technological University Singapore, 60 Nanyang Drive, Singapore 637551, Singapore
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Center for Integrative Genomics, Université de Lausanne, Le Génopode, CH-1015 Lausanne, Switzerland
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UMR 1331, Institut National de la Recherche Agronomique (INRA), Toxalim (Research Centre in Food Toxicology), 180, chemin de Tournefeuille, 1331 Toulouse, France
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Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(12), 4403; https://doi.org/10.3390/ijms21124403
Received: 1 May 2020 / Revised: 18 June 2020 / Accepted: 18 June 2020 / Published: 20 June 2020
(This article belongs to the Special Issue PPARs in Metabolic Regulation: Implications for Health and Disease)
Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in Pparβ/δ-deficient mice. However, PPARβ/δ’s role in physiological blood vessel formation and vessel remodeling in the retina has yet to be established. Our study showed that PPARβ/δ is specifically required for disordered blood vessel formation in the retina. We further demonstrated an increased arteriovenous crossover and wider venous caliber in Pparβ/δ-haplodeficient mice. In summary, these results indicated a critical role of PPARβ/δ in pathological angiogenesis and blood vessel remodeling in the retina. View Full-Text
Keywords: PPARβ/δ; angiogenesis; blood vessel remodeling; pericytes; vessel caliber; arteriovenous crossover PPARβ/δ; angiogenesis; blood vessel remodeling; pericytes; vessel caliber; arteriovenous crossover
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MDPI and ACS Style

Ho, S.Y.; Kwan, Y.P.; Qiu, B.; Tan, A.; Murray, H.L.; Barathi, V.A.; Tan, N.S.; Cheung, C.M.G.; Wong, T.Y.; Wahli, W.; Wang, X. Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice. Int. J. Mol. Sci. 2020, 21, 4403. https://doi.org/10.3390/ijms21124403

AMA Style

Ho SY, Kwan YP, Qiu B, Tan A, Murray HL, Barathi VA, Tan NS, Cheung CMG, Wong TY, Wahli W, Wang X. Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice. International Journal of Molecular Sciences. 2020; 21(12):4403. https://doi.org/10.3390/ijms21124403

Chicago/Turabian Style

Ho, Sze Y., Yuet P. Kwan, Beiying Qiu, Alison Tan, Hannah L. Murray, Veluchamy A. Barathi, Nguan S. Tan, Chui M.G. Cheung, Tien Y. Wong, Walter Wahli, and Xiaomeng Wang. 2020. "Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice" International Journal of Molecular Sciences 21, no. 12: 4403. https://doi.org/10.3390/ijms21124403

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