Next Article in Journal
The Role of Immune Checkpoints after Cellular Therapy
Previous Article in Journal
Hydrostatic Pressure Regulates Oxidative Stress through microRNA in Human Osteoarthritic Chondrocytes
Previous Article in Special Issue
MicroRNA 322 Aggravates Dexamethasone-Induced Muscle Atrophy by Targeting IGF1R and INSR
Open AccessArticle

Differential ESR1 Promoter Methylation in the Peripheral Blood—Findings from the Women 40+ Healthy Aging Study

1
Clinical Psychology and Psychotherapy, Department of Psychology, University of Zurich, 8050 Zurich, Switzerland
2
University Research Priority Program (URPP) Dynamics of Healthy Aging, University of Zurich, 8050 Zurich, Switzerland
3
Douglas Hospital Research Center, McGill University, Montreal, QC H4H 1R3, Canada
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(10), 3654; https://doi.org/10.3390/ijms21103654
Received: 21 April 2020 / Revised: 16 May 2020 / Accepted: 19 May 2020 / Published: 21 May 2020
(This article belongs to the Special Issue Steroid Metabolism in Human Health and Disease)
Background Estrogen receptor α (ERα) contributes to maintaining biological processes preserving health during aging. DNA methylation changes of ERα gene (ESR1) were established as playing a direct role in the regulation of ERα levels. In this study, we hypothesized decreased DNA methylation of ESR1 associated with postmenopause, lower estradiol (E2) levels, and increased age among healthy middle-aged and older women. Methods We assessed DNA methylation of ESR1 promoter region from dried blood spots (DBSs) and E2 from saliva samples in 130 healthy women aged 40–73 years. Results We found that postmenopause and lower E2 levels were associated with lower DNA methylation of a distal regulatory region, but not with DNA methylation of proximal promoters. Conclusion Our results indicate that decreased methylation of ESR1 cytosine-phosphate-guanine island (CpGI) shore may be associated with conditions of lower E2 in older healthy women. View Full-Text
Keywords: ESR1 promoter; DNA methylation; CpGI shore; estradiol; women healthy aging ESR1 promoter; DNA methylation; CpGI shore; estradiol; women healthy aging
Show Figures

Graphical abstract

MDPI and ACS Style

Gardini, E.S.; Chen, G.G.; Fiacco, S.; Mernone, L.; Willi, J.; Turecki, G.; Ehlert, U. Differential ESR1 Promoter Methylation in the Peripheral Blood—Findings from the Women 40+ Healthy Aging Study. Int. J. Mol. Sci. 2020, 21, 3654.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop