Expression and Function of Host Defense Peptides at Inflammation Sites
Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Mickiewicza 2c, Bialystok 15-222, Poland
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Int. J. Mol. Sci. 2020, 21(1), 104; https://doi.org/10.3390/ijms21010104
Received: 12 November 2019
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Revised: 9 December 2019
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Accepted: 19 December 2019
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Published: 22 December 2019
(This article belongs to the Special Issue Peptides for Health Benefits 2019)
There is a growing interest in the complex role of host defense peptides (HDPs) in the pathophysiology of several immune-mediated inflammatory diseases. The physicochemical properties and selective interaction of HDPs with various receptors define their immunomodulatory effects. However, it is quite challenging to understand their function because some HDPs play opposing pro-inflammatory and anti-inflammatory roles, depending on their expression level within the site of inflammation. While it is known that HDPs maintain constitutive host protection against invading microorganisms, the inducible nature of HDPs in various cells and tissues is an important aspect of the molecular events of inflammation. This review outlines the biological functions and emerging roles of HDPs in different inflammatory conditions. We further discuss the current data on the clinical relevance of impaired HDPs expression in inflammation and selected diseases.
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Keywords:
host defense peptides; human antimicrobial peptides; defensins; cathelicidins; inflammation; anti-inflammatory; pro-inflammatory
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MDPI and ACS Style
Prasad, S.V.; Fiedoruk, K.; Daniluk, T.; Piktel, E.; Bucki, R. Expression and Function of Host Defense Peptides at Inflammation Sites. Int. J. Mol. Sci. 2020, 21, 104. https://doi.org/10.3390/ijms21010104
AMA Style
Prasad SV, Fiedoruk K, Daniluk T, Piktel E, Bucki R. Expression and Function of Host Defense Peptides at Inflammation Sites. International Journal of Molecular Sciences. 2020; 21(1):104. https://doi.org/10.3390/ijms21010104
Chicago/Turabian StylePrasad, Suhanya V., Krzysztof Fiedoruk, Tamara Daniluk, Ewelina Piktel, and Robert Bucki. 2020. "Expression and Function of Host Defense Peptides at Inflammation Sites" International Journal of Molecular Sciences 21, no. 1: 104. https://doi.org/10.3390/ijms21010104
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