Next Article in Journal
The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights
Previous Article in Journal
The Burden of Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: Screening Issue and Future Perspectives
Open AccessReview

Pathogenic Effects of Impaired Retrieval between the Endoplasmic Reticulum and Golgi Complex

by Hiroshi Kokubun 1,†, Hisayo Jin 1,† and Tomohiko Aoe 2,*
1
Department of Anesthesiology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
2
Department of Medicine, Pain Center, Chiba Medical Center, Teikyo University, Ichihara 299-0111, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(22), 5614; https://doi.org/10.3390/ijms20225614 (registering DOI)
Received: 2 October 2019 / Revised: 31 October 2019 / Accepted: 7 November 2019 / Published: 9 November 2019
Cellular activities, such as growth and secretion, are dependent on correct protein folding and intracellular protein transport. Injury, like ischemia, malnutrition, and invasion of toxic substances, affect the folding environment in the endoplasmic reticulum (ER). The ER senses this information, following which cells adapt their response to varied situations through the unfolded protein response. Activation of the KDEL receptor, resulting from the secretion from the ER of chaperones containing the KDEL sequence, plays an important role in this adaptation. The KDEL receptor was initially shown to be necessary for the retention of KDEL sequence-containing proteins in the ER. However, it has become clear that the activated KDEL receptor also regulates bidirectional transport between the ER and the Golgi complex, as well as from the Golgi to the secretory pathway. In addition, it has been suggested that the signal for KDEL receptor activation may also affect several other cellular activities. In this review, we discuss KDEL receptor-mediated bidirectional transport and signaling and describe disease models and human diseases related to KDEL receptor dysfunction. View Full-Text
Keywords: KDEL receptor; endoplasmic reticulum; chaperone; protein quality control; proteostasis; unfolded protein response; ER stress; COPI; GPCR KDEL receptor; endoplasmic reticulum; chaperone; protein quality control; proteostasis; unfolded protein response; ER stress; COPI; GPCR
Show Figures

Figure 1

MDPI and ACS Style

Kokubun, H.; Jin, H.; Aoe, T. Pathogenic Effects of Impaired Retrieval between the Endoplasmic Reticulum and Golgi Complex. Int. J. Mol. Sci. 2019, 20, 5614.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop