Next Article in Journal
The Effects of Poncirus fructus on Insulin Resistance and the Macrophage-Mediated Inflammatory Response in High Fat Diet-Induced Obese Mice
Previous Article in Journal
Experimental Approaches and Computational Modeling of Rat Serum Albumin and Its Interaction with Piperine
Article Menu

Export Article

Open AccessCommunication

Non-Ionic Deep Eutectic Liquids: Acetamide–Urea Derived Room Temperature Solvents

Bioorganic & Biophysical Chemistry Laboratory, Linnaeus Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, SE-391 82 Kalmar, Sweden
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(12), 2857;
Received: 21 May 2019 / Revised: 29 May 2019 / Accepted: 30 May 2019 / Published: 12 June 2019
(This article belongs to the Section Molecular Biophysics)
PDF [2312 KB, uploaded 12 June 2019]


A family of non-ionic deep eutectic liquids has been developed based upon mixtures of solid N-alkyl derivatives of urea and acetamide that in some cases have melting points below room temperature. The eutectic behaviour and physical characteristics of a series of eleven eutectic mixtures are presented, along with a molecular dynamics study-supported hypothesis for the origin of the non-ideal mixing of these substances. Their use as solvents in applications ranging from natural product extraction to organic and polymer synthesis are demonstrated. View Full-Text
Keywords: deep-eutectic solvent; flickering cluster; acetamide–urea deep-eutectic solvent; flickering cluster; acetamide–urea

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Suriyanarayanan, S.; Olsson, G.D.; Kathiravan, S.; Ndizeye, N.; Nicholls, I.A. Non-Ionic Deep Eutectic Liquids: Acetamide–Urea Derived Room Temperature Solvents. Int. J. Mol. Sci. 2019, 20, 2857.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top