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Int. J. Mol. Sci. 2018, 19(9), 2732; https://doi.org/10.3390/ijms19092732

NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation

Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
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Received: 29 August 2018 / Revised: 9 September 2018 / Accepted: 10 September 2018 / Published: 12 September 2018
(This article belongs to the Special Issue Liver Damage and Repair)
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Abstract

In sterile liver inflammation, danger signals are released in response to tissue injury to alert the immune system; e.g., by activation of the NLRP3 inflammasome. Recently, IL-33 has been identified as a novel type of danger signal or “alarmin”, which is released from damaged and necrotic cells. IL-33 is a pleiotropic cytokine that targets a broad range of immune cells and exhibits pro- and anti-inflammatory properties dependent on the disease. This review summarizes the immunomodulatory roles of the NLRP3 inflammasome and IL-33 in sterile liver inflammation and highlights potential therapeutic strategies targeting these pathways in liver disease. View Full-Text
Keywords: sterile liver inflammation; NLRP3 inflammasome; IL-1β; IL-33; ILC2; tregs sterile liver inflammation; NLRP3 inflammasome; IL-1β; IL-33; ILC2; tregs
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Neumann, K.; Schiller, B.; Tiegs, G. NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation. Int. J. Mol. Sci. 2018, 19, 2732.

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