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Open AccessArticle

Fc Gamma Receptor IIb Expressed in Hepatocytes Promotes Lipid Accumulation and Gluconeogenesis

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing 100005, China
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Int. J. Mol. Sci. 2018, 19(10), 2932; https://doi.org/10.3390/ijms19102932
Received: 10 August 2018 / Revised: 3 September 2018 / Accepted: 8 September 2018 / Published: 26 September 2018
(This article belongs to the Special Issue Liver Damage and Repair)
Non-alcoholic fatty liver disease (NAFLD) is characterized by ectopic lipid accumulation in the liver, usually combined with hepatic insulin resistance. Fc-gamma receptor-IIb (FcγRIIb) and its ligand are reported to be associated with obesity and type 2 diabetes mellitus (T2DM). As knowledge about FcγRIIb in the literature is mostly generated from studies on skeletal muscle tissue, the expression and function of FcγRIIb in the liver and hepatocytes are largely unknown. In this study, we identified the expression of FcγRIIb in primary cultured mouse hepatocytes: FcγRIIb was upregulated in response to oleic acid (OA) in a dose dependent manner. FcγRIIb knockdown using shRNA suppressed the lipid and triglyceride accumulation, and mRNA expression of ACC1, FASn, CD36, MTTP, and ApoB in OA-treated HepG2 cells. FcγRIIb deficiency mice fed with high fat diet (HFD) had significantly lower liver weight and liver to body weight ratio, as well as less triglyceride accumulation in the livers. In glycometabolism, FcγRIIb hindered insulin-induced phosphorylation of AKT and FOXO1, and in turn upregulated G6Pase and PEPCK mRNA expression, suggesting that FcγRIIb promotes gluconeogenesis by suppressing the AKT/FOXO1/G6Pase/PEPCK pathway in hepatocytes. This study reveals a novel role for FcγRIIb in regulating lipid metabolism and glycometabolism, and provides a new therapeutic target to improve NAFLD. View Full-Text
Keywords: FcγRIIb; NAFLD; gluconeogenesis; insulin sensitivity FcγRIIb; NAFLD; gluconeogenesis; insulin sensitivity
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MDPI and ACS Style

Shu, T.; Song, X.; Cui, X.; Ge, W.; Gao, R.; Wang, J. Fc Gamma Receptor IIb Expressed in Hepatocytes Promotes Lipid Accumulation and Gluconeogenesis. Int. J. Mol. Sci. 2018, 19, 2932. https://doi.org/10.3390/ijms19102932

AMA Style

Shu T, Song X, Cui X, Ge W, Gao R, Wang J. Fc Gamma Receptor IIb Expressed in Hepatocytes Promotes Lipid Accumulation and Gluconeogenesis. International Journal of Molecular Sciences. 2018; 19(10):2932. https://doi.org/10.3390/ijms19102932

Chicago/Turabian Style

Shu, Ting; Song, Xiaomin; Cui, Xingxing; Ge, Weipeng; Gao, Ran; Wang, Jing. 2018. "Fc Gamma Receptor IIb Expressed in Hepatocytes Promotes Lipid Accumulation and Gluconeogenesis" Int. J. Mol. Sci. 19, no. 10: 2932. https://doi.org/10.3390/ijms19102932

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