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Int. J. Mol. Sci. 2018, 19(9), 2593; https://doi.org/10.3390/ijms19092593

Effects of Dietary Fibre from the Traditional Indonesian Food, Green Cincau (Premna oblongifolia Merr.) on Preneoplastic Lesions and Short Chain Fatty Acid Production in an Azoxymethane Rat Model of Colon Cancer

1
College of Science and Engineering, Flinders University, GPO Box 2100, Adelaide 5001, Australia
2
Flinders Centre for Innovation in Cancer, Flinders University, GPO Box 2100, Adelaide 5001, Australia
3
School of Science, RMIT University, P.O. Box 71, Bundoora, Victoria 3083, Australia
Current address: Research Center for Nutrition, Health and Herbal, University of Lampung, Bandar Lampung 35145, Indonesia.
Current address: Central Northern Adelaide Renal & Transplantation Service, Royal Adelaide Hospital, Adelaide 5001, Australia.
*
Author to whom correspondence should be addressed.
Received: 29 June 2018 / Revised: 20 August 2018 / Accepted: 21 August 2018 / Published: 31 August 2018
(This article belongs to the Special Issue Dietary Fibre: New Insights on Biochemistry and Health Benefits)
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Abstract

Green cincau (Premna oblongifolia Merr.) is a traditional food of Indonesia and provides a natural source of dietary fibre and antioxidants. This study evaluated the ability of green cincau, and other dietary fibres with or without the addition of anti-oxidant, epigallocatechin-3-gallate (EGCG), to prevent colorectal cancer in a 12 week azoxymethane (AOM) rat model. While all dietary treatments stimulated short chain fatty acid production (SCFA) in the digesta and faeces, no one treatment was able to significantly protect against aberrant crypt formation (ACF), when compared to the control diet. However, feeding green cincau leaves or extracts did not result in an increase in ACF compared to the control diet. Unexpectedly, when the dietary fibre source was pectin, 0.1% EGCG increased proliferative activity and liver lipid peroxidation when compared to the control diet containing cellulose. Examination of faecal microbial communities identified the presence of short chain acid producing bacteria, but a distinct community profile was not observed from any individual diet group. Overall, this research implies that combining dietary fibre with an antioxidant does not automatically equate to a beneficial response. Further work is required to investigate the health-promoting properties of green cincau. View Full-Text
Keywords: aberrant crypt foci; antioxidant; azoxymethane; colorectal cancer; dietary fibre; green cincau; gut microbiota; short chain fatty acids aberrant crypt foci; antioxidant; azoxymethane; colorectal cancer; dietary fibre; green cincau; gut microbiota; short chain fatty acids
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Nurdin, S.U.; Le Leu, R.K.; Aburto-Medina, A.; Young, G.P.; Stangoulis, J.C.R.; Ball, A.S.; Abbott, C.A. Effects of Dietary Fibre from the Traditional Indonesian Food, Green Cincau (Premna oblongifolia Merr.) on Preneoplastic Lesions and Short Chain Fatty Acid Production in an Azoxymethane Rat Model of Colon Cancer. Int. J. Mol. Sci. 2018, 19, 2593.

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